Normal pregnancy outcome after inadvertent exposure to long-acting gonadotrophin-releasing hormone agonist in early pregnancy

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dc.authorwosidtaskin, omur/C-6864-2016
dc.contributor.authorTaskin, O
dc.contributor.authorGokdeniz, R
dc.contributor.authorAtmaca, R
dc.contributor.authorBurak, F
dc.date.accessioned2024-08-04T20:12:01Z
dc.date.available2024-08-04T20:12:01Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFive infertile women exposed to long-acting gonadotrophin-releasing hormone agonist (GnRHa) during early pregnancy were studied to assess the risks of embryotoxicity on the outcome of their pregnancies. All the patients were diagnosed as stage 3-4 endometriosis following laparoscopy, Long-acting GnRHa (3.75 mg) was given in the first 3 days of their preceding menstrual period. Four of the five patients had two GnRHa injections and the last patient had three GnRHa injections. All patients were advised to use a barrier contraception (condoms) throughout the treatment period. Since all complained of no bleeding following the initial injections, human chorionic gonadotrophin (beta-HCG) concentrations were tested in order to rule out any pregnancy. Ultrasonographic examinations were commenced routinely and all patients had amniocentesis at 16-18 weeks gestational age. Genetic analysis revealed a normal karyotype in all fetuses. All five pregnancies progressed to term without complication, and normal healthy infants were delivered. Although there are still no clear answers concerning teratogenic and hormonal effects of GnRHa exposure in pregnancy, our data may suggest that luteal function, genetic structure and pregnancy outcome are not adversely affected by GnRHa, Since possible subtle effects on fetal endocrine organs cannot be disregarded, close monitoring is still needed in GnRHa-exposed pregnancies.en_US
dc.identifier.doi10.1093/humrep/14.5.1368
dc.identifier.endpage1371en_US
dc.identifier.issn0268-1161
dc.identifier.issue5en_US
dc.identifier.pmid10325295en_US
dc.identifier.scopus2-s2.0-0032946190en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1368en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/14.5.1368
dc.identifier.urihttps://hdl.handle.net/11616/93167
dc.identifier.volume14en_US
dc.identifier.wosWOS:000080426400046en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGnRHaen_US
dc.subjectluteolysisen_US
dc.subjectpregnancyen_US
dc.subjectteratogenicityen_US
dc.titleNormal pregnancy outcome after inadvertent exposure to long-acting gonadotrophin-releasing hormone agonist in early pregnancyen_US
dc.typeArticleen_US

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