Delayed gastric emptying in gastroesophageal reflux disease

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dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridAkin, Melih/0000-0001-9269-8001
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.contributor.authorDemirbilek, S
dc.contributor.authorKaraman, A
dc.contributor.authorGürünlüoglu, K
dc.contributor.authorAkin, M
dc.contributor.authorTas, E
dc.contributor.authorAksoy, RT
dc.contributor.authorKekilli, E
dc.date.accessioned2024-08-04T20:14:49Z
dc.date.available2024-08-04T20:14:49Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe association between gastroesophageal reflux (GER) and intestinal malrotation (IM) has been well described. Delayed or impaired gastric emptying in IM is thought to be a contributing factor in the development of gastroesophageal reflux disease (GERD). The current study assessed the role of malrotation in delayed gastric emptying in children with GERD. We also evaluated the interactions between GERD, malrotation, gastric pH abnormalities, and gastric dysmotility. Sixty-seven patients between 1 and 5 years of age ( mean 3.08 +/- 1.2) and with symptoms of GER, such as emesis, reactive or recurrent lung disease, and/or growth retardation, were studied in 2001 - 2005. Upper and lower gastrointestinal contrast studies were performed for the diagnosis of malrotation. Gastric motility was evaluated with a liquid gastric emptying protocol. GER was documented by upper gastrointestinal studies, scintigraphy, and/or 24- h pH monitoring. In our series of 44 children with GERD, there was an unexpectedly high incidence of IM: 54.5% (24/44). IM has previously been known to occur in 25% of patients with GERD. GERD was found in 24 (82.7%) of 29 patients with IM. Mean nuclear gastric emptying (MNGE) was 51.6 +/- 8.04 min in patients with isolated GERD and 96.6 +/- 20.5 min in children with IM and GERD. There was a statistically significant difference in MNGE time ( p< 0.05) between children with primary GERD and in those with GERD and IM. Esophageal pH monitoring showed that mean fraction time below pH 4 was 7.06 +/- 1.1% in patients with isolated GERD and 14.7 +/- 4.1% in patients with IM and GERD. GERD is common in children between 1 and 5 years old. Using gastric emptying studies and esophageal pH monitoring, we have shown that gastric dysmotility and esophageal pH abnormalities are highly prevalent, especially in children with malrotation compared with children with isolated GERD. These findings suggest that malrotation is an important factor responsible for delayed gastric emptying in GERD. Hence, we recommend that all infants and children with GERD and delayed gastric emptying undergo careful evaluation for malrotation.en_US
dc.identifier.doi10.1007/s00383-005-1460-3
dc.identifier.endpage427en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue6en_US
dc.identifier.pmid15912364en_US
dc.identifier.scopus2-s2.0-21544452578en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage423en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-005-1460-3
dc.identifier.urihttps://hdl.handle.net/11616/93990
dc.identifier.volume21en_US
dc.identifier.wosWOS:000229731500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgastroesophageal reflux diseaseen_US
dc.subjectintestinal malrotationen_US
dc.subjectgastric emptyingen_US
dc.subjectgastric dysmotilityen_US
dc.titleDelayed gastric emptying in gastroesophageal reflux diseaseen_US
dc.typeArticleen_US

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