Protective effect of thymoquinone against cyclophosphamide-induced genotoxic damage in human lymphocytes

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dc.authoridKorkmaz Sezer, Selcen/0000-0001-9479-3176
dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authorwosidKorkmaz Sezer, Selcen/ABU-1678-2022
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.contributor.authorYuksel, S.
dc.contributor.authorTasdemir, S.
dc.contributor.authorKorkmaz, S.
dc.date.accessioned2024-08-04T20:43:09Z
dc.date.available2024-08-04T20:43:09Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Protective effect of thymoquinone (TQ) against the cytotoxic and genotoxic effects of cyclophosphamide (CP) was assessed in human peripheral blood lymphocyte culture. METHODS: Mitotic indices were determined as endpoints of cytotoxicity, while sister chromatid exchanges (SCE) served as endpoints of genotoxicity. Firstly, the genotoxic effect of 0.16 mu g/ml of CP was tested and CP was detected as genotoxic. In the second set, CP group was treated with 20 mu M and 40 mu M TQ. RESULTS: TQ reduced the SCE frequencies, suggesting its protective action on human lymphocytes in vitro against the CP induced genotoxic damage. CONCLUSIONS: Our results suggest that TQ produces a protective mechanism against CP-induced genetic damage, and suggest a role of DNA strand breaks in the genotoxicity (Tab. 1, Fig. 1, Ref. 19). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2017_041
dc.identifier.endpage211en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue4en_US
dc.identifier.pmid28471230en_US
dc.identifier.scopus2-s2.0-85018931700en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_041
dc.identifier.urihttps://hdl.handle.net/11616/97804
dc.identifier.volume118en_US
dc.identifier.wosWOS:000401303100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectthymoquinoneen_US
dc.subjectcyclophosphamideen_US
dc.subjecthuman lymphocytesen_US
dc.subjectgenotoxicityen_US
dc.titleProtective effect of thymoquinone against cyclophosphamide-induced genotoxic damage in human lymphocytesen_US
dc.typeArticleen_US

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