Effect of ozone on colon anastomoses in rat peritonitis model

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dc.authoridavcı, sema/0000-0002-2860-5592
dc.authoridSoylu, Hakan/0000-0002-1177-2351
dc.authoridTekeli, Seckin Ozgur/0000-0002-4430-1134
dc.authoridCakir, Tugrul/0000-0001-7952-8462
dc.authorwosidavcı, sema/I-8850-2017
dc.authorwosidSoylu, Hakan/I-8911-2017
dc.authorwosidUstunel, İsmail/I-8932-2017
dc.authorwosidAslaner, Arif/AAH-9024-2020
dc.authorwosidÇakır, Tuğrul/AAD-1906-2019
dc.authorwosidAkyüz, Cebrail/AGY-4201-2022
dc.contributor.authorCakir, Tugrul
dc.contributor.authorAslaner, Arif
dc.contributor.authorTekeli, Seckin Ozgur
dc.contributor.authorAvci, Sema
dc.contributor.authorDogan, Ugur
dc.contributor.authorTekeli, Feyza
dc.contributor.authorSoylu, Hakan
dc.date.accessioned2024-08-04T20:41:36Z
dc.date.available2024-08-04T20:41:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats. METHODS: Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in groups 2 and 3. The medical ozone theraphy was administered intraperitonealy for three weeks in group 3 while the other rats received saline injection. At the twenty second day serum were obtained for TNF-alpha and IL-1 beta, the colonic burst pressures were measured and colonic tissue samples were obtained for MDA and MPO levels. Histolopatological examination was evaluated with H&E stain, and Ki-67, IL-1 beta and the VEGF immunostaining densities were also compared. RESULTS: Intraperitoneal ozone administration reversed TNF-alpha, IL-1 beta, MDA and MPO levels and the colonic burst pressures. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSION: Medical ozone therapy may contribute to tissue healing by affecting the proliferation and the vascularization thus has benefits on colonic anastomosis at peritonitis in rats.en_US
dc.identifier.doi10.1590/S0102-865020160020000005
dc.identifier.endpage118en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue2en_US
dc.identifier.pmid26959620en_US
dc.identifier.scopus2-s2.0-84960441340en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160020000005
dc.identifier.urihttps://hdl.handle.net/11616/97221
dc.identifier.volume31en_US
dc.identifier.wosWOS:000372808700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColonen_US
dc.subjectAnastomosis, Surgicalen_US
dc.subjectPeritonitisen_US
dc.subjectRatsen_US
dc.titleEffect of ozone on colon anastomoses in rat peritonitis modelen_US
dc.typeArticleen_US

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