Neuroprotective effect of transient receptor potential Vanilloid 1 agonist capsaicin in Alzheimer?s disease model induced with okadaic acid

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dc.authoridYuksel, Furkan/0000-0002-1503-265X
dc.authoridOZKUT, MAHMUD MUSTAFA/0000-0001-8725-8909
dc.authorwosidDurhan, Merve/JOK-8847-2023
dc.authorwosidYuksel, Furkan/KHD-2785-2024
dc.authorwosidOZKUT, MAHMUD MUSTAFA/A-5027-2019
dc.contributor.authorCakir, Murat
dc.contributor.authorYuksel, Furkan
dc.contributor.authorOzkut, Mahmud Mustafa
dc.contributor.authorDurhan, Merve
dc.contributor.authorKaymak, Emin
dc.contributor.authorTekin, Suat
dc.contributor.authorCigremis, Yilmaz
dc.date.accessioned2024-08-04T20:53:34Z
dc.date.available2024-08-04T20:53:34Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The presence of Transient Receptor Potential Vanilloid 1 (TRPV1) channels was detected in many regions of the human and rat brain, including the cortex and hippocampus. TRPV1 channels have functions such as the modulation of synaptic transmission and plasticity and the regulation of cognitive functions. Previous studies conducted with TRPV1 agonists and antagonists show that this channel is associated with the neuro-degenerative process. In the present study, the purpose was to investigate the effects of capsaicin, which is a TRPV1 agonist, and capsazepine, a TRPV1 antagonist, in the Alzheimer's Disease (AD) model that was induced by intracerebroventricular (ICV) administration of okadaic acid (OKA). Methods: The AD-like experimental model was created with bilateral ICV OKA injection. Intraperitoneal capsaicin and capsazepine injections were administered to the treatment groups for 13 days and histological and immu-nohistochemical examinations were performed from the cortex and hippocampal CA3 regions of the brain. The Morris Water Maze Test was used for spatial memory measurement.Results: ICV OKA administration increased the levels of caspase-3, phosphorylated-tau-(ser396), A beta, TNF-alpha, and IL1-beta, from the cortex and hippocampal CA3 regions of the brain and decreased the phosphorylated-Glycogen synthase kinase-3 beta-(ser9) levels. In addition, the OKA administration corrupted the spatial memory. The TRPV1 agonist capsaicin reversed the pathological changes induced by ICV OKA administration, but not the TRPV1 antagonist capsazepine.Conclusions: It was found in the study that the administration of the TRPV1 agonist capsaicin reduced neuro-degeneration, neuroinflammation, and deterioration in spatial memory in the AD model induced by OKA.en_US
dc.description.sponsorshipDepartment of Scientific Research Projects of Bozok University [6602c-TF/20-383]en_US
dc.description.sponsorshipThis study was supported by the Department of Scientific Research Projects of Bozok University (Project no: 6602c-TF/20-383) . Competing interests declared.en_US
dc.identifier.doi10.1016/j.intimp.2023.109925
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid37011502en_US
dc.identifier.scopus2-s2.0-85151391287en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2023.109925
dc.identifier.urihttps://hdl.handle.net/11616/101267
dc.identifier.volume118en_US
dc.identifier.wosWOS:000966459400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Immunopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer?s diseaseen_US
dc.subjectOkadaic aciden_US
dc.subjectTransient receptor potential vanilloid 1en_US
dc.subjectCapsaicinen_US
dc.subjectCapsazepineen_US
dc.titleNeuroprotective effect of transient receptor potential Vanilloid 1 agonist capsaicin in Alzheimer?s disease model induced with okadaic aciden_US
dc.typeArticleen_US

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