Novel platinum-N-heterocyclic carbene complex is more cardiotoxic than cis-platin in rats

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorVardi, Nigar
dc.contributor.authorGurbuz, Nevin
dc.date.accessioned2024-08-04T20:35:33Z
dc.date.available2024-08-04T20:35:33Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCis-platin and other platinum complexes are important chemotherapeutic agents useful in the treatment of several cancers. However, therapeutic usage of cis-platin and other platinum complex are limited by their undesirable side effects including cardiotoxicity. In this context, we aimed to compare the damage caused in heart by cis-platin and novel platinum-N-heterocyclic carbene (Pt-NHC) complex. For this purpose, 35 Sprague-Dawley rats were divided randomly into five equal groups (n = 7 for each group). Cis-platin and novel Pt-NHC complex were intraperitoneally administered at a single dose of 5 mg/kg and 10 mg/kg and then sacrificed 10 days after this treatment. The heart tissues were taken from all rats for determination of oxidative and myocardial damage. Cis-platin and novel Pt-NHC complex caused oxidative and histological damage in the heart tissue in a dose-dependent manner (p < 0.05). On the other hand, at the same dose levels, cis-platin caused lower oxidative and histological damage in heart tissue compared to novel Pt-NHC complex. These results suggest that novel Pt-NHC complex is more cardiotoxic than cis-platin.en_US
dc.description.sponsorshipTUBITAK; TUBITAK (Scientific and Technical Research Council of the Turkish Republic) [109T540]en_US
dc.description.sponsorshipIt is a great pleasure to thank TUBITAK for their financial support during our project.; We acknowledge the support of TUBITAK (Scientific and Technical Research Council of the Turkish Republic) under Grant 109T540.en_US
dc.identifier.doi10.1177/0960327110390064
dc.identifier.endpage1349en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue9en_US
dc.identifier.pmid21075807en_US
dc.identifier.scopus2-s2.0-80052553891en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1342en_US
dc.identifier.urihttps://doi.org/10.1177/0960327110390064
dc.identifier.urihttps://hdl.handle.net/11616/95435
dc.identifier.volume30en_US
dc.identifier.wosWOS:000294473300022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCis-platinen_US
dc.subjectplatin-NHC complexen_US
dc.subjectoxidative stressen_US
dc.subjectcardiotoxicityen_US
dc.titleNovel platinum-N-heterocyclic carbene complex is more cardiotoxic than cis-platin in ratsen_US
dc.typeArticleen_US

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