Evaluation of Cytotoxic Effect of Graphene Oxide Added to Mineral Trioxide Aggregate

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dc.authoridDAYI, Burak/0000-0002-5289-438X
dc.authorwosidDAYI, Burak/ABH-6633-2020
dc.contributor.authorDayi, Burak
dc.contributor.authorKuecuekyildiz, Elif Nihan
dc.contributor.authorTaghizadehghalehjoughi, Ali
dc.date.accessioned2024-08-04T20:53:44Z
dc.date.available2024-08-04T20:53:44Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim:Recently, although studies have shown that biomaterials containing graphene oxide (GO) in biomedicine stand out for their positive effects, the effect of GO on dental tissues when used with dental materials is not well known. The aim of this study was an evaluation of the cytotoxic effects of GO on gingival fibroblasts when it is combined in two different ratios with Mineral Trioxide Aggregate (MTA). Materials and Methods:In this in-vitro study, a homogenous mixture of adding +0.1 weight (wt)% and +0.3 wt% GO to Angelus MTA was created (two experimental groups) and compared with pure Angelus MTA and negative control groups. The materials were mixed according to the manufacturer's instructions, and Teflon molds were used to form 24 disc-shaped samples for each group. The samples were divided into groups according to the simple random sampling method. The cytotoxic effect of samples was determined on gingival fibroblast cells by using the MTT test, and total oxidant status (TOS) and total antioxidant capacity (TAC) kits in 24 and 72 hours. The data were statistically analyzed using one-way ANOVA and Tukey tests. Results:A significant difference was found between the material-applied groups and the control group at the TAC 24 and 72 hours and between the groups containing GO and the control group at the MTT 72 hours and TAC and TOS 24 and 72 hours (p < .05). Conclusion:The addition of GO to MTA increased the dose and time-based toxicity and oxidant amount, and decreased antioxidant capacity.en_US
dc.description.sponsorshipResearch Fund of the Inonu University [TCD-2018-1271]en_US
dc.description.sponsorshipThis research was supported by the Research Fund of the Inonu University [Project Number: TCD-2018-1271].en_US
dc.identifier.doi10.1177/23202068221142422
dc.identifier.endpage28en_US
dc.identifier.issn2320-2068
dc.identifier.issn2320-2076
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85160435879en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1177/23202068221142422
dc.identifier.urihttps://hdl.handle.net/11616/101375
dc.identifier.volume14en_US
dc.identifier.wosWOS:000978032000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications India Pvt Ltden_US
dc.relation.ispartofJournal of Advanced Oral Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngelus MTAen_US
dc.subjectCell Viabilityen_US
dc.subjectGraphene Oxideen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleEvaluation of Cytotoxic Effect of Graphene Oxide Added to Mineral Trioxide Aggregateen_US
dc.typeArticleen_US

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