Effects of dexmedetomidine and midazolam on motor coordination and analgesia a comparative analysis

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dc.authorid113863en_US
dc.authorid102000en_US
dc.authorid116272en_US
dc.authorid105949en_US
dc.authorid114271en_US
dc.authorid9712en_US
dc.contributor.authorAydoğan, Mustafa Said
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorErdoğan, Mehmet Ali
dc.contributor.authorYücel, Aytaç
dc.contributor.authorUçar, Muharrem
dc.contributor.authorSağır, Mustafa
dc.contributor.authorÇolak, Cemil
dc.date.accessioned2017-12-25T07:04:03Z
dc.date.available2017-12-25T07:04:03Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.descriptionCurrent Therapeutic Research, 75, 22–26.en_US
dc.description.abstractObjective: We compared the effects of 2 sedative drugs, dexmedetomidine and midazolam, on motor performance and analgesic efficacy in a rat model. Materials and methods: Rats were randomly divided into the following 4 groups on the basis of the treatment received. The first group received 83 mg/kg/min midazolam; the second, 1 mg/kg/min dexmedetomidine; the third, 83 mg/kg/min morphine; and the fourth was a control group. The rats were measured motor coordination and pain reflexes by using rotarod, accelerod, hot plate, and tail flick tests. Results: At all the tested speeds, the midazolam-injected rats remained on the rotarod longer than did the dexmedetomidine-injected rats. Furthermore, in the 10-minute accelerod test, the midazolaminjected rats remained for a longer duration than did the dexmedetomidine-injected rats. The latency time for the hot plate test was significantly higher at 10 minutes and 20 minutes in the dexmedetomidine group than in the midazolam group. Further, the latency time at 10 minutes for the tail flick test was greater in the dexmedetomidine group than in the midazolam group. Conclusions: In this rat model, midazolam results in faster recovery of motor coordination performance when compared with dexmedetomidine.en_US
dc.identifier.citationAydoğan, M. S., Parlakpınar, H., Erdoğan, M. A., Yücel, A., Uçar, M., Sağır, M., & Çolak, C. (2013). Effects Of Dexmedetomidine And Midazolam On Motor Coordination And Analgesia A Comparative Analysis. Current Therapeutic Research, 75, 22–26.en_US
dc.identifier.doi10.1016/j.curtheres.2013.05.003en_US
dc.identifier.endpage26en_US
dc.identifier.issue0en_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898185/pdf/main.pdf
dc.identifier.urihttps://hdl.handle.net/11616/7926
dc.identifier.volume75en_US
dc.language.isoenen_US
dc.publisherCurrent Therapeutic Researchen_US
dc.relation.ispartofCurrent Therapeutic Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcceleroden_US
dc.subjectDexmedetomidineen_US
dc.subjectHot plateen_US
dc.subjectMidazolamen_US
dc.subjectMotor impairmenten_US
dc.subjectRotaroden_US
dc.subjectTail flicken_US
dc.titleEffects of dexmedetomidine and midazolam on motor coordination and analgesia a comparative analysisen_US
dc.typeArticleen_US

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