Therapeutic plasma exchange in neuroimmunologic disease: 60 patients experience
| dc.contributor.author | Ilgen Uslu, Ferda | |
| dc.contributor.author | Gursoy, Azize Esra | |
| dc.date.accessioned | 2022-03-15T12:07:16Z | |
| dc.date.available | 2022-03-15T12:07:16Z | |
| dc.date.issued | 2021 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: We aimed to determine the results, safety, and applicability of therapeutic plasma exchange (TPE) in neurological diseases. Materials and Methods: We performed a retrospective analysis in between 2014-2019. In the evaluation of response to treatment (RT), patients were divided into 4 groups: full recovery (RT1), partial recovery (RT2), stationary or worse (RT3), exitus (RT4). TPE treatment was evaluated effective in patients with RT1 and RT2. Patients' data were compared between group 1 (TPE as first line treatment) and group 2 (TPE as additional therapy). Results: TPE procedure was applied to 199 patients, 1330 times. Sixty neurological patients (mean age 51.5±17.05; 24 female) underwent 356 TPE procedures on average 6.2 sessions. After TPE, functional status was RT1:3, RT2:19, RT3:28, RT:10. TPE was an effective treatment in 36.6% of patients. Disease distribution Guillain Barre syndrome (n:26), myasthenia gravis (n:8), autoimmune encephalitis (n:6), neuromyelitis optica (n:5), transverse myelitis (n:5), vasculitis (n:3), chronic demyelinating inflammatory polyneuropathy (n:2), multiple sclerosis (n:2), Morvan syndrome (n:1), myeloradiculitis (n:1) and polymyositis (n:1). 7 patients (11.6%) were included in group 1 and 53 patients were in group 2. TPE was started after 9.7 days (±6.9) due to insufficient response. Complications were found in 6 patients (10%). The duration of hospitalization was 28.1 (±13.1) in group 1 and 32.9 (±19) days in group 2 (p: 0.01). Conclusion: Our experience has supported that TPE is a safe and effective treatment option for a wide range of antibody-related neurological disorders, especially if it is the first treatment option. | en_US |
| dc.identifier.citation | Uslu, F. I., & Gursoy, A. E. (2021). Therapeutic plasma exchange in neuroimmunologic disease: 60 patients experience. Annals of Medical Research, | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/55690 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Therapeutic plasma exchange in neuroimmunologic disease: 60 patients experience | en_US |
| dc.type | Article | en_US |
