Preliminary Results on Antigenotoxic Effects of Dried Mycelia of Two Medicinal Mushrooms in Drosophila melanogaster Somatic Mutation and Recombination Test

Basit Öğe Kaydı
dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.contributor.authorKylyc, Aygul
dc.contributor.authorYesilada, Elif
dc.date.accessioned2024-08-04T20:37:41Z
dc.date.available2024-08-04T20:37:41Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the antigenotoxic effects of dried mycelia from Trametes versicolor and Pleurotus ostreatus were investigated using a Drosophila melanogaster somatic mutation and recombination test (SMART), which is based on the principle that the loss of heterozygosity of suitable recessive marker hairs, such as multiple wing (mwh) and flare-3 (flr(3)), can lead to the formation of mutant clones of larval cells, which then are expressed as spots on the wings of the adult flies. In this study, dried mycelia from T versicolor and P. ostreatus alone (7.5, 15, and 30 mg) were examined for genotoxicity and combined with mitomycin C (MMC; 0.05 mM) for antigenotoxicity. Commonly known mutagen which is mitomycin C (MMC) was used as positive control. The results showed that the dried mycelia of mushrooms were not genotoxic themselves. Nevertheless, the mushrooms have antigenotoxic activity by reducing the frequency of MMC-induced spots in varying proportions. Thus, powders of these 2 fungi were able to suppress somatic cell mutation induced by MMC. These results suggest that T versicolor and P ostreatus have antigenotoxic activity, including antirecombinogenic activity.en_US
dc.description.sponsorshipScientific Research Unit of the Inonu University (I.U. BAP) [2007/34]en_US
dc.description.sponsorshipWe thank Dr. Ozfer Yesilada for his comments and suggestions. This work was supported by the Scientific Research Unit of the Inonu University (I.U. BAP) (project no. 2007/34).en_US
dc.identifier.doi10.1615/IntJMedMushr.v15.i4.90
dc.identifier.endpage421en_US
dc.identifier.issn1521-9437
dc.identifier.issn1940-4344
dc.identifier.issue4en_US
dc.identifier.pmid23796223en_US
dc.identifier.scopus2-s2.0-84879035811en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1615/IntJMedMushr.v15.i4.90
dc.identifier.urihttps://hdl.handle.net/11616/96098
dc.identifier.volume15en_US
dc.identifier.wosWOS:000320968300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBegell House Incen_US
dc.relation.ispartofInternational Journal of Medicinal Mushroomsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmedicinal mushroomsen_US
dc.subjectantigenotoxicityen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectSMART testen_US
dc.subjectTrametes versicoloren_US
dc.subjectPleurotus ostreatusen_US
dc.subjectmitomycin-C (MMC)en_US
dc.titlePreliminary Results on Antigenotoxic Effects of Dried Mycelia of Two Medicinal Mushrooms in Drosophila melanogaster Somatic Mutation and Recombination Testen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu