Integrated assessment of biochemical markers in premetamorphic tadpoles of three amphibian species exposed to glyphosate- and methidathion-based pesticides in single and combination forms

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dc.authoridYoloğlu, Ertan/0000-0002-9730-9471
dc.authoridGüngördü, Abbas/0000-0001-7770-0660
dc.authoridUÇKUN, Miraç/0000-0002-9018-8515
dc.authorwosidYoloğlu, Ertan/W-2811-2017
dc.authorwosidMiraç, Uçkun/ABG-5824-2021
dc.authorwosidGüngördü, Abbas/A-3009-2015
dc.authorwosidUÇKUN, Miraç/ABC-4209-2021
dc.contributor.authorGungordu, Abbas
dc.contributor.authorUckun, Mirac
dc.contributor.authorYologlu, Ertan
dc.date.accessioned2024-08-04T20:41:26Z
dc.date.available2024-08-04T20:41:26Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we evaluated the toxic effects of a glyphosate-based herbicide (GBH) and a methidathion-based insecticide (MBI), individually and in combination, on premetamorphic tadpoles of three anuran species: Pelophylax ridibundus, Xenopus laevis, and Bufotes viridis. Based on the determined 96-h LC50 values of each species, the effects of a series of sublethal concentrations of single pesticides and their mixtures after 96-h exposure and also the time-related effects of a high sublethal concentration of each pesticide were evaluated, with determination of changes in selected biomarkers: glutathione S-transferase (GST), glutathione reductase (GR), acetylcholinesterase (AChE), carboxylesterase (CaE), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). Also, the integrated biomarker response (IBR) was used to assess biomarker responses and quantitatively evaluate toxicological effects. Isozyme differences in CaE inhibition were assessed using native page electrophoresis; results showed that GBH to cause structural changes in the enzyme but not CaE inhibition in P. ridibundus. In general, single MBI and pesticide mixture exposures increased GST activity, while single GBH exposures decreased GST activity in exposed tadpoles. The AChE and CaE activities were inhibited after exposure to all single MBI and pesticide mixtures. Also, higher IBR values and GST, GR, AST, and LDH activities were determined for pesticide mixtures compared with single-pesticide exposure. This situation may be indicative of a synergistic interaction between pesticides and a sign of a more stressful condition. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.chemosphere.2015.10.125
dc.identifier.endpage2035en_US
dc.identifier.issn0045-6535
dc.identifier.issn1879-1298
dc.identifier.pmid26595308en_US
dc.identifier.scopus2-s2.0-84953776385en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2024en_US
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2015.10.125
dc.identifier.urihttps://hdl.handle.net/11616/97107
dc.identifier.volume144en_US
dc.identifier.wosWOS:000367774400257en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofChemosphereen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmphibiaen_US
dc.subjectGlyphosateen_US
dc.subjectMethidathionen_US
dc.subjectPesticide mixtureen_US
dc.subjectBiochemical markersen_US
dc.titleIntegrated assessment of biochemical markers in premetamorphic tadpoles of three amphibian species exposed to glyphosate- and methidathion-based pesticides in single and combination formsen_US
dc.typeArticleen_US

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