Protective effect of extracts of teucrium polium and rumex crispus against cyclophosphamide-induced genotoxic damage in human lymphocytes

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dc.authorscopusid12797912000
dc.authorscopusid57530724700
dc.authorscopusid55218229500
dc.authorscopusid57190845490
dc.contributor.authorYuksel S.
dc.contributor.authorSezer S.K.
dc.contributor.authorKurtoglu E.L.
dc.contributor.authorBag H.G.
dc.date.accessioned2024-08-04T20:02:35Z
dc.date.available2024-08-04T20:02:35Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTeucrium polium (T. polium) and Rumex crispus (R. crispus) are plant species that grow widely in Anatolia and are thought to have healing effects for many diseases. In this study plant extracts are suggested as alternative agents in repairing cellular damage by using sister chromatid exchange (SCE), micronucleus (MN), mitotic index (MI), replication index (RI) and nuclear abnormalities (NAs), against the genotoxicity of cyclophosphamide (CP) in the human lymphocyte cells. 8 experimental groups were formed in the study. The cell culture medium was supplemented with 0.16 ?g/ml CP and the cells were treated with 50, 100 and 250 ?M T. polium and R. crispus extracts in the presence and absence of CP. As a result, CP significantly decreased MI frequency while increasing SCE, MN and NAs frequencies in cells. 100 ?M T. polium plus CP decreased SCEs when compared with CP alone. In addition, MN frequency was significantly decreased in 100 ?M T. polium plus CP and 250 ?M R. crispus plus CP combine groups. Our results suggest that these plant extracts are not genetically damaging and have improving effects at these doses. © 2019 Eco-Vector LLC. All rights reserved.en_US
dc.identifier.doi10.17816/ecogen17293-100
dc.identifier.endpage100en_US
dc.identifier.issn1811-0932
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85069056138en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.17816/ecogen17293-100
dc.identifier.urihttps://hdl.handle.net/11616/91808
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEco-Vector LLCen_US
dc.relation.ispartofEcological Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectGenotoxicityen_US
dc.subjectHuman lymphocytesen_US
dc.subjectRumex crispusen_US
dc.subjectTeucrium poliumen_US
dc.titleProtective effect of extracts of teucrium polium and rumex crispus against cyclophosphamide-induced genotoxic damage in human lymphocytesen_US
dc.typeArticleen_US

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