Synthesis, characterization, biological determination and catalytic evaluation of ruthenium(ii) complexes bearing benzimidazole-based NHC ligands in transfer hydrogenation catalysis

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dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidchakchouk, ahlem/JYP-3425-2024
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorSlimani, Ichraf
dc.contributor.authorChakchouk-Mtibaa, A.
dc.contributor.authorMansour, L.
dc.contributor.authorMellouli, L.
dc.contributor.authorOzdemir, I
dc.contributor.authorGurbuzd, Nevin
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:47:14Z
dc.date.available2024-08-04T20:47:14Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA new series of ruthenium(ii) N-heterocyclic carbene complexes has been synthesized via transmetalation. These complexes are easily handled in very good yields via synthesis of silver-NHC complexes and subsequent reaction with [RuCl2(p-cymene)](2) in dichloromethane (DCM) under argon atmosphere. The new ruthenium(ii)-NHC complexes were applied to transfer hydrogenation of ketone derivatives using 2-propanol as a hydrogen source and KOH as a co-catalyst. The results show that the corresponding alcohols could be obtained in good yield with high catalyst activity (up to 76%) under mild conditions. All new compounds were characterized by spectroscopic and analytical methods. The antibacterial activities of the corresponding ruthenium(ii)-NHC complexes 4a-i were tested against positive and negative bacteria using the agar dilution procedure and their IC50 values have been determined. A cytotoxicity study of the ruthenium(ii)-NHC complexes 4 was performed against the two human cancer cell lines MDA-MB-231 and MCF-7. In addition, the scavenging activity of the synthesized complexes for the DPPH radical was also determined.en_US
dc.description.sponsorshipKing Saud University, Riyadh Saudi Arabia [RSP2019/75]en_US
dc.description.sponsorshipThis work was funded by the Research Supporting Project (RSP2019/75), King Saud University, Riyadh Saudi Arabia.en_US
dc.identifier.doi10.1039/d0nj00311e
dc.identifier.endpage5323en_US
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue14en_US
dc.identifier.scopus2-s2.0-85083039285en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5309en_US
dc.identifier.urihttps://doi.org/10.1039/d0nj00311e
dc.identifier.urihttps://hdl.handle.net/11616/99246
dc.identifier.volume44en_US
dc.identifier.wosWOS:000524498200015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofNew Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeterocyclic Carbene Complexesen_US
dc.subjectAsymmetric Transfer Hydrogenationen_US
dc.subjectMetal-Complexesen_US
dc.subjectStructural-Characterizationen_US
dc.subjectOlefin Metathesisen_US
dc.subjectAryl Chloridesen_US
dc.subjectSystemen_US
dc.subjectKetonesen_US
dc.subjectActivationen_US
dc.subjectCisplatinen_US
dc.titleSynthesis, characterization, biological determination and catalytic evaluation of ruthenium(ii) complexes bearing benzimidazole-based NHC ligands in transfer hydrogenation catalysisen_US
dc.typeArticleen_US

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