Investigation of the relationship between Epstein-Barr virus and ordinary gastric carcinoma using the nested polymerase chain reaction

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dc.authoridkoroglu, mehmet/0000-0001-8101-1104
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidkoroglu, mehmet/HTN-0171-2023
dc.contributor.authorDurmaz, R
dc.contributor.authorAydin, A
dc.contributor.authorKöroglu, M
dc.contributor.authorDurmaz, B
dc.contributor.authorÇiralik, H
dc.date.accessioned2024-08-04T20:11:59Z
dc.date.available2024-08-04T20:11:59Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo investigate whether Epstein-Barr virus (EBV) is associated with ordinary gastric carcinoma and to determine its genotype, samples from ordinary gastric carcinoma from 65 patients (40 males, 20 females) and 21 endoscopic biopsies from 7 individuals with non-neoplastic mucosa were analysed using one-stage and nested (two-stage) polymerase chain reaction (PCR) assays. The nested PCR assay yielded 56.9% (37/65) and 52.3% (11/21) positivity for the ordinary gastric carcinoma and control cases, respectively; these results were significantly than those of the one-stage PCR assay(13.5% and 0%, respectively). The EBV positivity showed similar rate in male and female patients (60% versus 52%, P > 0.05). The dominant genotype of EBV was 1 (92%) followed by mixture of 1+2 (5.4%) and 2 (2.6%). In conclusion, similar positivity rates of EBV in neoplastic and non-neoplastic tissues suggest that the relationship of this virus to the ordinary gastric carcinoma is not clear.en_US
dc.identifier.endpage363en_US
dc.identifier.issn0001-723X
dc.identifier.issue6en_US
dc.identifier.pmid10358740en_US
dc.identifier.scopus2-s2.0-0032414441en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://hdl.handle.net/11616/93133
dc.identifier.volume42en_US
dc.identifier.wosWOS:000079531900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSlovak Academic Press Ltden_US
dc.relation.ispartofActa Virologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpstein-Barr virusen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectgastric adenocarcinomaen_US
dc.subjectvirus genotypeen_US
dc.titleInvestigation of the relationship between Epstein-Barr virus and ordinary gastric carcinoma using the nested polymerase chain reactionen_US
dc.typeArticleen_US

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