Renal and mesenteric tissue oxygenation in preterm infants treated with oral ibuprofen

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dc.authoridOGUZ, SUNA SERIFE/0000-0002-1870-0983;
dc.authorwosidOGUZ, SUNA SERIFE/GWZ-7382-2022
dc.authorwosidaltug, nahide/AAH-9878-2019
dc.authorwosidUras, Nurdan/AAR-5383-2020
dc.contributor.authorGuzoglu, Nilufer
dc.contributor.authorSari, Fatma Nur
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorOguz, Serife Suna
dc.contributor.authorUras, Nurdan
dc.contributor.authorAltug, Nahide
dc.contributor.authorDilmen, Ugur
dc.date.accessioned2024-08-04T20:38:00Z
dc.date.available2024-08-04T20:38:00Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Hemodynamically significant patent ductus arteriosus (PDA) is a common problem in preterm infants which often causes significant morbidities. Although PDA induces alterations in various tissue perfusion, there is scarce information about the effect of oral ibuprofen on hemodynamics of regional tissues. Objective: To investigate, using near-infrared spectroscopy, the effect of oral ibuprofen on renal and mesenteric tissue oxygenation and oxygen extraction in preterm infants with a diagnosis of hemodynamically significant PDA. Patients and methods: Fifteen infants (gestational age <32 weeks) with the diagnosis of hemodynamically significant PDA treated with oral ibuprofen were monitored for near-infrared spectroscopy - determined renal and mesenteric oxygenation. The infants with PDA were matched for gestational age, postnatal age with infants without PDA, who served as control subjects. Results: In infants with PDA, mean arterial blood pressure was significantly lower compared with the control infants [39.3 (range: 36-54) versus 51 (range: 43-66) mmHg, respectively; p < 0.001)]. There were no significant differences in regional oxygen saturation and fractional oxygen extraction of renal and mesenteric tissues in PDA and control infants (p > 0.05). And ibuprofen treatment did not negatively influence renal and mesenteric oxygenation and extraction in infants with PDA (p > 0.05). Conclusion: Renal and mesenteric tissue oxygenation and oxygen extraction were preserved in preterm infants with a diagnosis of hemodynamically significant PDA treated with oral ibuprofen.en_US
dc.identifier.doi10.3109/14767058.2013.811485
dc.identifier.endpage203en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue2en_US
dc.identifier.pmid23735121en_US
dc.identifier.scopus2-s2.0-84890516908en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2013.811485
dc.identifier.urihttps://hdl.handle.net/11616/96309
dc.identifier.volume27en_US
dc.identifier.wosWOS:000328259500015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIbuprofenen_US
dc.subjectpatent ductus arteriosusen_US
dc.subjectregional oxygen saturationen_US
dc.titleRenal and mesenteric tissue oxygenation in preterm infants treated with oral ibuprofenen_US
dc.typeArticleen_US

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