Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage
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Tarih
2009
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: AMAÇ: Bu çalışma serum ve beyin omurilik sıvısı (BOS) S100B protein düzey ölçümlerinin gebelerde serebral hasarı saptamadaki rolünü araştırmak için planlandı. GEREÇ VE YÖNTEM: Yaşları 20-34 arasında değişen 14 gebe hastadan sezaryen operasyonu için yapılan spinal anestezi esnasında serum ve BOS örnekleri alındı. Gebe olmayan ve organik bir beyin hastalığı bulunmayan 9 sağlıklı kadından alınan serum örnekleri ise kontrol grubu olarak belirlendi. Serum ve BOS S100B protein düzeyleri electrochemiluminescence yöntemiyle çalışıldı. Kontrol grubu ve gebelerin serum ve BOS S100B düzeyleri Kruskal-Wallis ve Mann-Whitney Utest kullanılarak karşılaştırıldı. BULGULAR: Gebe kadınların serum S100B protein düzeyleri [0.66 ± 0.06 ng/ml] gebe olmayanlardan [0.06 ± 0.00 ng/ml] anlamlı olarak daha yüksek saptandı (p<.0001). Gebe kadınların BOS S100B protein düzeyleri serum S100B protein düzeylerinden anlamlı olarak yüksek bulundu (p<0.05). Ancak iki dü- zey arasındaki korelasyon anlamlı değildi (p=0.473). Ge be ler - de BOS S100B protein düzeyleri gebe olmayanların serum S100B protein düzeylerinden anlamlı olarak yüksek saptandı (p<0.0001).
Abstract: OBJECTIVE: The aim of the study was to consider logical basis of serum and cerebrospinal fluid (CSF) S100B measurement in pregnant females to detect any cerebral damage. STUDY DESIGN: CSF and serum samples from 14 pregnant patients (age: 20-34 years) were obtained during spinal anesthetic procedure of cesarean section. The serum samples from 9 non-pregnant patients (22-36 years) without an organic brain disease were used as normative data. S-100B levels in serum and CSF samples were measured with electrochemiluminescence immunoassay method. The CSF and blood serum levels of pregnants and blood serum levels of pregnant and nonpregnant females were compared using Kruskal-Wallis and Mann-Whitney U-tests. RESULTS: Serum S100B protein levels of pregnant females were significantly higher [0.66±0.06 ng/ml] than those observed in [0.06±0.00 ng/ml] nonpregnant females (p<.0001). There was a significant difference between the S100B protein levels of CSF and blood serum (p<0.05) in pregnant females. However the correlation between these two levels was insignificant (p=0.473). CSF S100B levels of pregnant subjcets were significantly higher than the serum levels of pregnant and nonpregnant subjects (p<0.0001). DISCUSSION: These results prove that the maternal serum and CSF S100B protein levels are independently related to each other in pregnancy.
Abstract: OBJECTIVE: The aim of the study was to consider logical basis of serum and cerebrospinal fluid (CSF) S100B measurement in pregnant females to detect any cerebral damage. STUDY DESIGN: CSF and serum samples from 14 pregnant patients (age: 20-34 years) were obtained during spinal anesthetic procedure of cesarean section. The serum samples from 9 non-pregnant patients (22-36 years) without an organic brain disease were used as normative data. S-100B levels in serum and CSF samples were measured with electrochemiluminescence immunoassay method. The CSF and blood serum levels of pregnants and blood serum levels of pregnant and nonpregnant females were compared using Kruskal-Wallis and Mann-Whitney U-tests. RESULTS: Serum S100B protein levels of pregnant females were significantly higher [0.66±0.06 ng/ml] than those observed in [0.06±0.00 ng/ml] nonpregnant females (p<.0001). There was a significant difference between the S100B protein levels of CSF and blood serum (p<0.05) in pregnant females. However the correlation between these two levels was insignificant (p=0.473). CSF S100B levels of pregnant subjcets were significantly higher than the serum levels of pregnant and nonpregnant subjects (p<0.0001). DISCUSSION: These results prove that the maternal serum and CSF S100B protein levels are independently related to each other in pregnancy.
Açıklama
Anahtar Kelimeler
Kaynak
GORM:Gynecology Obstetrics & Reproductive Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
15
Sayı
2
Künye
ÇELİK N,ÇELİK Ö,CANPOLAT H,EVLİYAOĞLU O,KARAKAŞ H. M (2009). Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage. GORM:Gynecology Obstetrics & Reproductive Medicine, 15(2), 81 - 84.
