Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study

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dc.authoridsolak, eda öksüm/0000-0002-1362-7801
dc.authoridalbayrak, hulya/0000-0002-2022-578X
dc.authoridarıca, deniz aksu/0000-0003-3755-4325
dc.authoridTürkmen, Dursun/0000-0001-9076-4669
dc.authoridTemiz, Selami Aykut/0000-0003-4878-0045
dc.authoridSavas Erdogan, Sevil/0000-0002-4392-4671
dc.authorwosidsolak, eda öksüm/AAN-3665-2021
dc.authorwosidPolat Ekinci, Algün/JDW-8990-2023
dc.authorwosidalbayrak, hulya/ABC-9901-2020
dc.authorwosidDEMİRBAŞ, ABDULLAH/AAI-7147-2020
dc.authorwosidarıca, deniz aksu/AAL-5510-2021
dc.authorwosidli, juqian/KII-7123-2024
dc.authorwosidTürkmen, Dursun/ABG-3801-2020
dc.contributor.authorCebeci Kahraman, Filiz
dc.contributor.authorSavas Erdogan, Sevil
dc.contributor.authorAktas, Nurhan Doner
dc.contributor.authorAlbayrak, Hulya
dc.contributor.authorTurkmen, Dursun
dc.contributor.authorBorlu, Murat
dc.contributor.authorArica, Deniz Aksu
dc.date.accessioned2024-08-04T20:52:09Z
dc.date.available2024-08-04T20:52:09Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives In this study covering all of Turkey, we aimed to define cutaneous and systemic adverse reactions in our patient population after COVID-19 vaccination with the Sinovac/CoronaVac (inactivated SARS-CoV-2) and Pfizer/BioNTech (BNT162b2) vaccines. Methods This prospective, cross-sectional study included individuals presenting to the dermatology or emergency outpatient clinics of a total of 19 centers after having been vaccinated with the COVID-19 vaccines. Systemic, local injection site, and non-local cutaneous reactions after vaccination were identified, and their rates were determined. Results Of the 2290 individuals vaccinated between April 15 and July 15, 2021, 2097 (91.6%) received the CoronaVac vaccine and 183 (8%) BioNTech. Systemic reactions were observed at a rate of 31.0% after the first CoronaVac dose, 31.1% after the second CoronaVac dose, 46.4% after the first BioNTech dose, and 46.2% after the second BioNTech dose. Local injection site reactions were detected at a rate of 35.6% after the first CoronaVac dose, 35.7% after the second CoronaVac dose, 86.9% after the first BioNTech dose, and 94.1% after the second BioNTech dose. A total of 133 non-local cutaneous reactions were identified after the CoronaVac vaccine (2.9% after the first dose and 3.5% after the second dose), with the most common being urticaria/angioedema, pityriasis rosea, herpes zoster, and maculopapular rash. After BioNTech, 39 non-local cutaneous reactions were observed to have developed (24.8% after the first dose and 5% after the second dose), and the most common were herpes zoster, delayed large local reaction, pityriasis rosea, and urticaria/angioedema in order of frequency. Existing autoimmune diseases were triggered in 2.1% of the patients vaccinated with CoronaVac and 8.2% of those vaccinated with BioNTech. Conclusions There are no comprehensive data on cutaneous adverse reactions specific to the CoronaVac vaccine. We determined the frequency of adverse reactions from the dermatologist's point of view after CoronaVac and BioNTech vaccination and identified a wide spectrum of non-local cutaneous reactions. Our data show that CoronaVac is associated with less harmful reactions while BioNTech may result in more serious reactions, such as herpes zoster, anaphylaxis, and triggering of autoimmunity. However, most of these reactions were self-limiting or required little therapeutic intervention.en_US
dc.identifier.doi10.1111/jocd.15209
dc.identifier.endpage3703en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue9en_US
dc.identifier.pmid35780311en_US
dc.identifier.scopus2-s2.0-85134228318en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3692en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.15209
dc.identifier.urihttps://hdl.handle.net/11616/100784
dc.identifier.volume21en_US
dc.identifier.wosWOS:000827105400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleCutaneous reactions after COVID-19 vaccination in Turkey: A multicenter studyen_US
dc.typeArticleen_US

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