DO disease stages affect oxidative stress in stable COPD?

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dc.authoridARSLAN, Ahmet Kadir/0000-0001-8626-9542
dc.authorwosidARSLAN, Ahmet Kadir/AAA-2409-2020
dc.contributor.authorYalcinsoy, Murat
dc.contributor.authorBeykumul, Aysegul
dc.contributor.authorGulbas, Gazi
dc.contributor.authorArslan, Ahmet Kadir
dc.contributor.authorNeselioglu, Salim
dc.date.accessioned2024-08-04T20:56:03Z
dc.date.available2024-08-04T20:56:03Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Detection of oxidative stress level may lead us to understand the pathogenesis of COPD better and to search for new treatments. Oxidative stress levels have also been shown to be elevated in stable COPD patients. We aimed to investigate whether the stage of COPD affects the severity of inflammation-induced oxidative stress in patients with stable COPD. Methods: Between June 2019 and March 2020, all consecutive patients admitted to COPD-specific outpatient clinics were included. Patients were classified A, B, and E according to the GOLD guideline. Results: The median age of 98 patients (Male: 92 (93.9 %)) was 65 (min-max: 49-86). A statistically significant difference was found between the groups in FEV1, FVC, and FEV1/FVC (p < 0.001). age, and thiols (r = -0.168, p = 0.049; r = -0.184, p = 0.035) and DS (r = -0.209, p = 0.019) were found to be negatively correlated at a low level. When adjusted for age, oxidative stress parameters were similar between stages. Conclusion: No difference between stages and oxidative stress parameters according to GOLD classification in stable COPD patients. Our results may be a guide for not using anti-inflammatory therapy except for attacks.en_US
dc.identifier.doi10.1016/j.heliyon.2024.e31188
dc.identifier.issn2405-8440
dc.identifier.issue10en_US
dc.identifier.pmid38831835en_US
dc.identifier.scopus2-s2.0-85193859013en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e31188
dc.identifier.urihttps://hdl.handle.net/11616/102008
dc.identifier.volume10en_US
dc.identifier.wosWOS:001246533700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofHeliyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOPDen_US
dc.subjectOxidative stressen_US
dc.subjectCOPD stagesen_US
dc.subjectThiolen_US
dc.subjectDisulfideen_US
dc.titleDO disease stages affect oxidative stress in stable COPD?en_US
dc.typeArticleen_US

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