Preparation of Molecularly Imprinted Metoprolol Sensor from Poly(aniline-co-p-toluene sulfonic acid)

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dc.authoridgungor, oznur/0000-0002-0664-1218
dc.contributor.authorGungor, Oznur
dc.contributor.authorHassine, Chedia Ben Ali
dc.contributor.authorBurc, Muammer
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorDuran, Serap Titretir
dc.date.accessioned2024-08-04T20:51:54Z
dc.date.available2024-08-04T20:51:54Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the metoprolol (MTP), which is a beta-blocker class molecule used in hypertension treatment, was determined by modifying the glassy carbon electrode (GCE) with a molecular imprinting technique. Firstly, p-toluene sulfonic acid (PTSA) and aniline (AN) were co-electropolymerized in the presence of MTP as a template molecule on GCE and MTP contained poly(aniline-co-p-toluene sulfonic acid) (p(AN-co-PTSA)) film was obtained. Then, the template metoprolol molecule was desorbed from the conductive p(AN-co-PTSA) film structure on the GCE surface using hydrochloric acid. Obtained molecularly imprinted electrodes were used to determine MTP by the square wave voltammetry (SWV) method. The modified electrodes obtained showed a correlation coefficient (R-2) of 0.9995 in the 40-1500 mu M MTP concentration range. The limit of detection (LOD) and the limit of quantification (LOQ) of the p(AN-co-PTSA) film modified MTP electrodes were 37.9 mu M and 126.3 mu M, respectively. A standard deviation of 1.33% was observed for the first three replicates with the same modified electrode. For the time reproduced electrodes, stable reproducibility was achieved between the first electrode result and the tenth electrode result. For the modified MTP electrode, the relative standard deviation (RSD%) value was calculated to be 2.53%. As result, the molecularly imprinted electrodes prepared with p(AN-co-PTSA) film have low response time, high reproducibility, good stability, and high selectivity for the determination of MTP.en_US
dc.description.sponsorshipInonu University Scientific Research Project Unit by Grant BAP [FHD-2020-2008]en_US
dc.description.sponsorshipThe authors thank the financial support from the Inonu University Scientific Research Project Unit by Grant BAP (FHD-2020-2008).en_US
dc.identifier.endpage302en_US
dc.identifier.issn2008-4226
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85128511222en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://hdl.handle.net/11616/100611
dc.identifier.volume14en_US
dc.identifier.wosWOS:000782847500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Tehran, Fac Chemistry, Center Excellence Electrochemistryen_US
dc.relation.ispartofAnalytical & Bioanalytical Electrochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetoprololen_US
dc.subjectMolecularly imprinted electrodeen_US
dc.subjectElectropolymerizationen_US
dc.subjectSensoren_US
dc.subjectVoltammetryen_US
dc.titlePreparation of Molecularly Imprinted Metoprolol Sensor from Poly(aniline-co-p-toluene sulfonic acid)en_US
dc.typeArticleen_US

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