Ameliorative Effects of Resveratrol on Acute Ovarian Toxicity Induced by Total Body Irradiation in Young Adult Rats

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dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridözer, ali/0000-0002-7144-4915
dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidözer, ali/ABI-2209-2020
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorGurocak, Simay
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorCelik, Onder
dc.contributor.authorOzer, Ali
dc.contributor.authorYilmaz, Ercan
dc.date.accessioned2024-08-04T20:36:02Z
dc.date.available2024-08-04T20:36:02Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to investigate the ovarian protective effects of resveratrol in rats exposed to total body irradiation. Design: Experimental study. Settings: University hospital. Participants and Interventions: Thirty female rats were randomized into four groups: (1) control group (n = 7); (2) low-dose (10 mg/kg) resveratrol group (n = 8); (3) high-dose (100 mg/kg) resveratrol group (n =7); and (4) sham irradiation group (n = 8). The drugs were administered intraperitoneally as single doses, and the rats were exposed to total body radiation 24 h after the treatment. The animals were sacrificed the following day, and their ovaries were excised for histopathological and biochemical analysis. Main Outcome Measures: The ovarian follicle counts were calculated, and irradiation-dependent ovarian damage and tissue levels of antioxidant enzymes were evaluated. Results: Group 2 and Group 3 showed significantly higher numbers of total follicle counts compared with Group 1 (P < 0.01). The low-dose resveratrol treatment was associated with significantly higher numbers of primary follicles than the high-dose group. The tissue activities of glutathione peroxidase (GsH-Px) and catalase (CAT) were significantly elevated in the resveratrol-treated animals. Evaluation of ovarian histology revealed no remarkable changes in fibrosis and leucocyte infiltration among the resveratrol-treated and control rats; however, vascularity was significantly reduced in the high-dose group (P = 0.014). Conclusion: Resveratrol attenuated irradiation-dependent ovarian damage, suggesting that this natural antioxidant is effective in reducing the follicle loss induced by ionizing radiation.en_US
dc.identifier.doi10.1016/j.jpag.2012.04.001
dc.identifier.endpage266en_US
dc.identifier.issn1083-3188
dc.identifier.issn1873-4332
dc.identifier.issue4en_US
dc.identifier.pmid22840937en_US
dc.identifier.scopus2-s2.0-84864296515en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage262en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpag.2012.04.001
dc.identifier.urihttps://hdl.handle.net/11616/95740
dc.identifier.volume25en_US
dc.identifier.wosWOS:000307318900009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Pediatric and Adolescent Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiationen_US
dc.subjectOvarian follicleen_US
dc.subjectResveratrolen_US
dc.subjectOxidative stressen_US
dc.titleAmeliorative Effects of Resveratrol on Acute Ovarian Toxicity Induced by Total Body Irradiation in Young Adult Ratsen_US
dc.typeArticleen_US

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