Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186;
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidtürkmen, emine/GXH-9319-2022
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.contributor.authorKaraman, A
dc.contributor.authorFadillioglu, E
dc.contributor.authorTurkmen, E
dc.contributor.authorTas, E
dc.contributor.authorYilmaz, Z
dc.date.accessioned2024-08-04T20:15:25Z
dc.date.available2024-08-04T20:15:25Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatic ischemia-reperfusion (I/R) injury may be developed in some conditions, such as trauma, major hepatic resection, hemorrhagic shock or liver transplantation. I/R injury of the liver causes hepatocellular damage that may lead to hepatic failure. A considerable body of evidence indicates that reactive oxygen species (ROS) and inflammation may contribute to hepatocellular injury in liver I/R. Leflunomide is an isoxazole derivative, and a unique immunomodulatory agent. In the present study, we examined the effects of leflunomide on the neutrophil activation with oxidative stress and some antioxidant enzymes in the reperfusion following I/R in the rat liver. Thirty-two rats divided into four groups: group 1 (control); was given leflunomide 10 mg/kg, i.g.; group 2 (SHAM), animals were only laparotomized; group 3 (liver I/R), and group 4 (liver I/R + Leflunomide). In group 4, rats were pretreated with leflunomide (10 mg/kg, i.g.) two doses prior to experiment. In groups 3 and 4, occluding the hepatic pedicel for 60 min induced ischemia and reperfusion was allowed thereafter for 60 min. At the end of the reperfusion period, rats were sacrificed. superoxide dismutase, catalase, nitric oxide, xanthine oxidase, malondialdehyde, protein carbonyl and myeloperoxidase levels were determined in hepatic tissue as well as histological examination with H and E staining. Group 3 animals demonstrated severe deterioration of liver morphology and a significant liver oxidative stress. Pretreatment of animals with leflunomide markedly attenuated morphological alterations and neutrophil activation, reduced elevated oxidative stress products levels and restored the depleted hepatic antioxidant enzyme. The findings imply that ROS play a causal role in I/R-induced hepatic injury, and leflunomide exerts hepatoprotective effects probably by the anti-inflammatory effect with radical scavenging and antioxidant activities.en_US
dc.identifier.doi10.1007/s00383-006-1668-x
dc.identifier.endpage434en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue5en_US
dc.identifier.pmid16555109en_US
dc.identifier.scopus2-s2.0-33646453495en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-006-1668-x
dc.identifier.urihttps://hdl.handle.net/11616/94376
dc.identifier.volume22en_US
dc.identifier.wosWOS:000237192700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectliveren_US
dc.subjectischemia-reperfusionen_US
dc.subjectleflunomideen_US
dc.subjectoxidanten_US
dc.subjectmyeloperoxidaseen_US
dc.subjectantioxidantsen_US
dc.titleProtective effects of leflunomide against ischemia-reperfusion injury of the rat liveren_US
dc.typeArticleen_US

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