Effects of melatonin on acetylsalicylic acid induced gastroduodenal and jejunal mucosal injury

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dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidTaslidere, Bahadir/AAE-4204-2022
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorTaslidere, E.
dc.contributor.authorVardi, N.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorYildiz, A.
dc.contributor.authorTaslidere, B.
dc.contributor.authorKaraaslan, M. G.
dc.date.accessioned2024-08-04T20:45:31Z
dc.date.available2024-08-04T20:45:31Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe evaluated the effects of melatonin on acetylsalicylic acid (ASA) induced gastroduodenal and jejunal mucosal injury. We used 40 postpubertal rats divided randomly into five groups of eight animals. The control group consisted of untreated animals. The Mel group was injected intraperitoneally (i.p.) with 5mg/kg melatonin. The ASA group was injected i.p. with 200mg/kg ASA. The ASA + Mel group was injected i.p. with 5mg/kg melatonin 45min after administering 200mg/kg ASA i.p. The Mel + ASA group was injected i.p. with 5mg/kg melatonin 45min before administering 200mg/kg ASA i.p. We found no statistically significant differences in mean histopathological scores in the ASA + Mel group compared to the ASA group. ASA caused shortened villi and loss of the apical villus in the duodenum. The histopathological score was increased and villus height was decreased in the ASA group compared to untreated controls. Treatment with melatonin attenuated the histological damage. In the ASA group, occasional areas showed erosion of villi in the jejunum; however, differences in mean histopathological score in ASA group compared to the other groups were not statistically significant. Malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) activities were measured in stomach, duodenal and jejunum tissue. We found increased MDA activity in both stomach and duodenal tissues in the ASA group compared to the control group (p<0.05). We found no statistically significant changes in MDA levels in jejunal tissue in the ASA group compared to the control group. We found no change in SOD activity in either stomach or duodenal tissues in the ASA group compared to the control group. We observed decreased SOD activity in jejunal tissue in the ASA group compared to the control group (p<0.05). We detected no change in GSH activity in stomach, duodenal or jejunal tissues in the ASA group compared to the control group. The stomach damage was less in melatonin treated groups, but the lesions were not completely eliminated. The jejunum in the ASA group retained a nearly normal appearance. We found that melatonin exhibited some healing effects on ASA induced duodenal mucosal injury.en_US
dc.identifier.doi10.1080/10520295.2018.1442020
dc.identifier.endpage495en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue7en_US
dc.identifier.pmid30388896en_US
dc.identifier.scopus2-s2.0-85056159548en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage485en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1442020
dc.identifier.urihttps://hdl.handle.net/11616/98527
dc.identifier.volume93en_US
dc.identifier.wosWOS:000451798700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectaspirinen_US
dc.subjectduodenumen_US
dc.subjectjejunumen_US
dc.subjectmelatoninen_US
dc.subjectraten_US
dc.subjectstomachen_US
dc.titleEffects of melatonin on acetylsalicylic acid induced gastroduodenal and jejunal mucosal injuryen_US
dc.typeArticleen_US

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