Epidemiologic characterization of nosocomial Acinetobacter baumannii infections in a Turkish university hospital by pulsed-field gel electrophoresis

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dc.authoridKaya, Selçuk/0000-0002-8637-6345
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidKaya, Selçuk/HKW-3308-2023
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorCetin, Emel Sesli
dc.contributor.authorDurmaz, Riza
dc.contributor.authorTetik, Tulay
dc.contributor.authorOtlu, Baris
dc.contributor.authorKaya, Selcuk
dc.contributor.authorCaliskan, Ahmet
dc.date.accessioned2024-08-04T20:31:07Z
dc.date.available2024-08-04T20:31:07Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Although members of the Acinetobacter genus are not commonly part of the human flora, their relatively high prevalence in hospital environment frequently results in colonization of the skin and respiratory tract. Objectives: The present investigation was carried out to elucidate epidemiologic characteristics of nosocomial Acinetobacter baumannii infections in a teaching hospital. Methods: Epidemiologic, clinical, and demographic features of the 66 patients with A baumannii infection during a 14-month period were recorded. Antibiotic susceptibilities of the isolates were determined by the standardized disk-diffusion method, and the clonal relationship of the isolates was analyzed by pulsed-field gel electrophoresis (PFGE). Results: The incidence of A baumannii infection was especially high in January, April, May and June 2006. The isolates were most frequently obtained from blood and tracheal aspirates sent from the intensive care unit and neurosurgery ward. Although the most frequently identified predisposing factors were cerebrovascular disease and surgical operation, the main risk factors identified in these patients were catheterization and mechanical ventilation. Genotype analysis of the 66 A baumannii strains by PFGE revealed the circulation of 36 different PFGE types. of which type A (12) and K (17) accounted for 44% of the isolates. We found high clonal relationship (80.3%) among the typed strains. Thirteen antibiotypes were observed. Most of the isolates were multidrug resistant. Resistance to imipenem, meropenem, gentamicin, amikacin, tobramycin, netilmicin, ampicillin-sulbactam, trimethoprim-sulfamethoxazole, piperacillin-tazobactam, cefoperazone-sulbactam, ciprofloxacin, and levofloxacin were found in 44%, 47%, 47%, 84.8%, 21.2%, 3%, 62.1%, 57.6%, 94%, 62.1%, 95.5%, and 95.5% of the isolates, respectively. Conclusion: The epidemiologic data obtained suggested that the increase in the number of A baumannii infections in our hospital was caused by the interhospital spread of especially 2 epidemic clones. We determined that clonally related strains can survive for a long time in our hospital and cause nosocomial infections in the predisposed patients. (Am J Infect Control 2009;37:56-64.)en_US
dc.identifier.doi10.1016/j.ajic.2008.01.010
dc.identifier.endpage64en_US
dc.identifier.issn0196-6553
dc.identifier.issn1527-3296
dc.identifier.issue1en_US
dc.identifier.pmid18834735en_US
dc.identifier.scopus2-s2.0-58549111863en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajic.2008.01.010
dc.identifier.urihttps://hdl.handle.net/11616/94736
dc.identifier.volume37en_US
dc.identifier.wosWOS:000263480800009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofAmerican Journal of Infection Controlen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMolecular Epidemiologyen_US
dc.subjectAntimicrobial Resistanceen_US
dc.subjectPseudomonas-Aeruginosaen_US
dc.subjectCarbapenem Resistanceen_US
dc.subjectMultiresistanten_US
dc.subjectSpreaden_US
dc.subjectEmergenceen_US
dc.subjectStrainsen_US
dc.subjectIdentificationen_US
dc.subjectMulticenteren_US
dc.titleEpidemiologic characterization of nosocomial Acinetobacter baumannii infections in a Turkish university hospital by pulsed-field gel electrophoresisen_US
dc.typeArticleen_US

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