Subclinical left ventricular dysfunction in Behcet's disease assessed by two-dimensional speckle tracking echocardiography

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dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridTaşolar, Hakan/0000-0002-1249-7240
dc.authoridPekdemir, Hasan/0000-0002-4913-5120
dc.authoridAkaycan, Jülide/0000-0002-9174-6777;
dc.authorwosidSener, Serpil/ABI-6229-2020
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidTaşolar, Hakan/ABG-4466-2020
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidErmis, Necip/A-5184-2018
dc.contributor.authorYagmur, Julide
dc.contributor.authorSener, Serpil
dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorCansel, Mehmet
dc.contributor.authorErmis, Necip
dc.contributor.authorKarincaoglu, Yelda
dc.contributor.authorTasolar, Hakan
dc.date.accessioned2024-08-04T20:35:32Z
dc.date.available2024-08-04T20:35:32Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims The aim of this study was to evaluate the left ventricular (LV) systolic strain by speckle tracking echocardiography (STE) in order to provide the early detection of myocardial dysfunction in patients with Behcet's disease (BD). We also aimed to examine the relationship between LV systolic strain and N-terminal pro-B type natriuretic peptide (NT-proBNP), which is a cardiac biomarker of ventricular dysfunction. Methods and results Longitudinal and circumferential systolic strain assessed by STE was obtained in 32 BD patients and 27 age-matched controls. NT-proBNP levels were also measured in all subjects. Regional and mean longitudinal strain (-17.8 +/- 2.7 vs. -20.5 +/- 1.8%; P < 0.0001) was significantly lower in BD patients when compared with the healthy controls. Whereas regional and mean circumferential strain values (-22.0 +/- 1.6 vs. -22.2 +/- 2.3%; P = 0.62) did not reveal a significant difference between the patients and the controls. NT-proBNP was significantly higher in the patients than in the controls (65.18 +/- 84.51 vs. 30.84 +/- 14.75 pg/mL; P = 0.003). Linear regression analyses revealed only NT-proBNP as the independent correlate of mean LV longitudinal strain (R = 0.603, P = 0.001). Conclusion Longitudinal myocardial systolic function assessed by STE, which is a sensitive marker of subclinical ventricular dysfunction is impaired in BD. Increased NT-proBNP levels may be a sign of subclinical ventricular dysfunction in these patients.en_US
dc.identifier.doi10.1093/ejechocard/jer088
dc.identifier.endpage541en_US
dc.identifier.issn1525-2167
dc.identifier.issn1532-2114
dc.identifier.issue7en_US
dc.identifier.pmid21676963en_US
dc.identifier.scopus2-s2.0-80052019995en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage536en_US
dc.identifier.urihttps://doi.org/10.1093/ejechocard/jer088
dc.identifier.urihttps://hdl.handle.net/11616/95414
dc.identifier.volume12en_US
dc.identifier.wosWOS:000294110300011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofEuropean Journal of Echocardiographyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectSpeckle tracking echocardiographyen_US
dc.subjectN-terminal pro-B type natriuretic peptideen_US
dc.titleSubclinical left ventricular dysfunction in Behcet's disease assessed by two-dimensional speckle tracking echocardiographyen_US
dc.typeArticleen_US

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