Effects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct size

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorOzer, Mehmet Kaya
dc.contributor.authorAcet, Ahmet
dc.date.accessioned2024-08-04T20:35:38Z
dc.date.available2024-08-04T20:35:38Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe renin-angiotensin system (RAS) plays a major role in regulating the cardiovascular system, and disorders of the RAS contribute largely to the cardiac pathophysiology, including myocardial ischemia-reperfusion (MI/R) injury. Two subtypes of angiotensin II (Ang II) receptors have been defined on the basis of their differential pharmacological properties. The current study was undertaken to address the question as to whether the inhibition of the angiotensin converting enzyme (ACE) by captopril and the AT(1) and AT(2) receptor blockers losartan and PD123319 modulate MI/R-induced infarct size in an in vivo rat model. To produce necrosis, a branch of the descending left coronary artery was occluded for 30 min followed by two hours of reperfusion. ECG changes, blood pressure, and heart rate were measured during the experiment. Captopril (3 mg/kg), losartan (2 mg/kg), and PD123319 (20 mu g/kg/min) were given in an IV 10 min before ischemia and were continued during the ischemic period. The infarcted area was measured by TTC staining. The volume of infarct and the risk zone was determined by planimetry. Compared to the control group (55.62 +/- 4.00%) both captopril and losartan significantly reduced the myocardial infarct size (30.50 +/- 3.26% and 37.75 +/- 4.44%), whereas neither PD123319 nor PD123319+losartan affected the infarct size volume (46.50 +/- 3.72 and 54.62 +/- 2.43). Our data indicates that captopril and losartan exert cardioprotective activity after an MI/R injury. Also, infarct size reduction by losartan was halted by a blockade of the AT(2) receptor. Therefore, the activation of AT(2) receptors may be potentially protective and appear to oppose the effects mediated by the AT(1) receptors. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University/Malatya/Turkeyen_US
dc.description.sponsorshipThis study was supported by a Grant from The Scientific Research Fund of Inonu University/Malatya/Turkey.en_US
dc.identifier.doi10.1016/j.cyto.2011.09.002
dc.identifier.endpage694en_US
dc.identifier.issn1043-4666
dc.identifier.issn1096-0023
dc.identifier.issue3en_US
dc.identifier.pmid21975128en_US
dc.identifier.scopus2-s2.0-81455131541en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage688en_US
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2011.09.002
dc.identifier.urihttps://hdl.handle.net/11616/95492
dc.identifier.volume56en_US
dc.identifier.wosWOS:000298122700023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaptoprilen_US
dc.subjectLosartanen_US
dc.subjectPD123319en_US
dc.subjectAT(2) receptoren_US
dc.subjectMyocardial ischemia-reperfusionen_US
dc.titleEffects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct sizeen_US
dc.typeArticleen_US

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