Histopathological Changes that Occur on the Testicular and Penile Tissues Depending on the Treatment of Human Chorionic Gonadotropin: Rat Model

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dc.authorwosidYildirim, Serkan/AAH-6721-2020
dc.authorwosidOzan, Tunc/W-7432-2018
dc.contributor.authorPirincci, N.
dc.contributor.authorYildirim, S.
dc.contributor.authorTas, A.
dc.contributor.authorOzan, T.
dc.contributor.authorGecit, I
dc.contributor.authorOzveren, H.
dc.date.accessioned2024-08-04T20:44:39Z
dc.date.available2024-08-04T20:44:39Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To examine the histopathological effects of human chorionic gonadotropin (hCG) treatment on the penile and the testicular tissue in rat model. Methods: The rats of the hCG group (n = 8) were given daily subcutaneous injections of 50 IU of hCG for 15 days (Pregnyl, Organon). Rats of the control group (n = 8) received subcutaneous isotonic saline. All rats were sacrificed at the 1st month after hCG administration. After the received tissue samples were examined, germinal epithelial cell thickness, seminiferous tubule diameter; internal diameter of the tubules, the number of germ cell layers in the testicular tissue, and the diameters of penis, cavernous sinus lumen diameters and collagen tissue amount in the cavernous sinus surrounding were assessed in the sections prepared from the penis. Results: It was detected that there was a decrease in the testis weight, atrophy in the tubules, reduction in spermatogenesis, decrease in the mature spermatocytes, lower mean thickness and the number of cell layers of the germinal membrane in testicular tissue in the hCG group. It was found that the amount of collagen in the penile tissue was significantly higher in the hCG group and the diameters of cavernosal sinus lumens, and diameter of the penis were significantly lower in the hCG group. Conclusion: Human chorionic gonadotropin led to the deterioration in testicular histology and the histological changes in the penile tissue. The degradation in the testicular tissue and these changes formed in the penile tissue may affect the erectile tissue function.en_US
dc.identifier.doi10.7727/wimj.2015.282
dc.identifier.endpage318en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85049929852en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage315en_US
dc.identifier.urihttps://doi.org/10.7727/wimj.2015.282
dc.identifier.urihttps://hdl.handle.net/11616/98384
dc.identifier.volume69en_US
dc.identifier.wosWOS:000719641000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHistopathologyen_US
dc.subjecthuman chorionic gonadotropinen_US
dc.subjectpenileen_US
dc.subjectraten_US
dc.subjecttesticularen_US
dc.titleHistopathological Changes that Occur on the Testicular and Penile Tissues Depending on the Treatment of Human Chorionic Gonadotropin: Rat Modelen_US
dc.typeArticleen_US

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