Higher rate of COVID-19 mortality in patients with type 1 than type 2 diabetes: a nationwide study

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dc.authoridSonmez, Alper/0000-0002-9309-7715
dc.authoridBirinci, Suayip/0000-0001-8104-6198
dc.authoridDagdelen, Selcuk/0000-0002-0513-1750
dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.authoridSatman, Ilhan/0000-0001-8613-1797
dc.authoridDemirci, Ibrahim/0000-0003-0498-3115
dc.authoridTASCI, ILKER/0000-0002-0936-2476
dc.authorwosidSonmez, Alper/H-8588-2019
dc.authorwosidBirinci, Suayip/JFJ-4049-2023
dc.authorwosidDagdelen, Selcuk/A-9432-2017
dc.authorwosidsahin, mustafa/AAH-3394-2019
dc.authorwosidCelik, Osman/KLZ-6766-2024
dc.authorwosidUstun, Yaprak/KFQ-9767-2024
dc.authorwosidSatman, Ilhan/AAS-7044-2020
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorHaymana, Cem
dc.contributor.authorTasci, Ilker
dc.contributor.authorSatman, Ilhan
dc.contributor.authorAtmaca, Aysegul
dc.contributor.authorSahin, Mustafa
dc.contributor.authorAta, Naim
dc.date.accessioned2024-08-04T20:51:42Z
dc.date.available2024-08-04T20:51:42Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: COVID-19 disease has a worse prognosis in patients with diabetes, but comparative data about the course of COVID-19 in patients with type 1 (T1DM) and type 2 diabetes (T2DM) are lacking. The purpose of this study was to find out the relative clinical severity and mortality of COVID-19 patients with T1DM and T2DM. Material and methods: A nationwide retrospective cohort of patients with confirmed (PCR positive) COVID-19 infection (n = 149,671) was investigated. After exclusion of individuals with unspecified diabetes status, the adverse outcomes between patients with T1DM (n = 163), T2DM (n = 33,478) and those without diabetes (n = 115,108) were compared by using the propensity score matching method. The outcomes were hospitalization, the composite of intensive care unit (ICU) admission and/or mechanical ventilation, and mortality. Results: The patients with T1DM had higher mortality than the age- and gender-matched patients with T2DM (n = 489) and those without diabetes (n = 489) (p < 0.001). After further adjustment for the HbA(1c), and microvascular and macrovascular complications, the odds of mortality (OR: 3.35, 95% CI: 1.41-7.96, p = 0.006) and ICU admission and/or mechanical ventilation (OR: 2.95, 95% CI: 1.28-6.77, p = 0.011) were significantly higher in patients with T1DM compared to those with T2DM. Older age (OR: 1.06, 95% CI: 1.01-1.12, p = 0.028) and lymphopaenia (OR: 5.13, 95% CI: 1.04-25.5, p = 0.045) were independently associated with mortality in patients with T1DM. Conclusions: Patients with T1DM had worse prognosis of COVID-19 compared to T2DM patients or those without diabetes. These cases should be cared for diligently until more data become available about the causes of increased COVID-19 mortality in T1DM.en_US
dc.identifier.doi10.5603/EP.a2022.0008
dc.identifier.endpage95en_US
dc.identifier.issn0423-104X
dc.identifier.issue1en_US
dc.identifier.pmid35119089en_US
dc.identifier.scopus2-s2.0-85124979113en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.5603/EP.a2022.0008
dc.identifier.urihttps://hdl.handle.net/11616/100495
dc.identifier.volume73en_US
dc.identifier.wosWOS:000804688900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofEndokrynologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectcoronavirusen_US
dc.subjecttype 1 diabetesen_US
dc.subjectmortalityen_US
dc.subjectdiabetes mellitusen_US
dc.subjectT1DMen_US
dc.subjectTurkeyen_US
dc.titleHigher rate of COVID-19 mortality in patients with type 1 than type 2 diabetes: a nationwide studyen_US
dc.typeArticleen_US

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