Erdosteine ameliorates neurological outcome and oxidative stress due to ischemia/reperfusion injury in rabbit spinal cord

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dc.contributor.authorEge, E
dc.contributor.authorIlhan, A
dc.contributor.authorGurel, A
dc.contributor.authorAkyol, O
dc.contributor.authorOzen, S
dc.date.accessioned2024-08-04T20:30:50Z
dc.date.available2024-08-04T20:30:50Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective. Oxygen-derived free radicals have been suggested as important in degeneration after spinal cord ischemia. The aim of this study was to investigate whether erdosteine has a protective effect against spinal cord ischemia during aortic cross clamping. Materials and methods. New Zealand White rabbits (n = 21) were divided into three groups. In the ischemia/reperfusion group (I/R) (n = 8), the infrarenal aorta of rabbits was cross clamped for 21 min and then reperfused. In erdosteine group, the administration of erdosteine solution (50 mg/kg) was started two days before aortic cross-clamping and rabbits (n = 8) were subjected to ischemia and reperfusion. Animals in control group (n = 5) underwent a surgical procedure similar to the other groups but the aorta was not clamped. The animals were sacrificed at 72 h and histopathological, and biochemical analyses were carried out on the lumbar spinal cords. Results. Erdosteine treatment zoos associated with improved neurological function in the postoperative period. Histopathological examination of spinal cord tissues in erdosteine group revealed changes consistent with mild ischemic injury, but rabbits in I/R group with paraplegia had total destruction of the motor neurons. Biochemical analyses of spinal cord tissues, in the I/R group, revealed a significant increase in the superoxide dismutase, xanthine oxidase, adenosine deaminase and myeloperoxidase activities, and a significant depletion in glutathione peroxidase activity when compared to that of control rabbits. Erdosteine treatment prevented the increase of all these enzymes except adenosine deaminase. Ischemia/reperfusion produced a significant increase in the tissue malondialdehyde levels. Ischemia/reperfusion-induced increments in malondialdehyde content of the spinal cord were significantly prevented by erdosteine treatment. Conclusions. The present study demonstrated that erdosteine treatment before aortic cross clamping ameliorates neurological outcome, neuronal injury and oxidative stress in the rabbit spinal cord.en_US
dc.identifier.doi10.1016/j.ejvs.2004.06.004
dc.identifier.endpage386en_US
dc.identifier.issn1078-5884
dc.identifier.issue4en_US
dc.identifier.pmid15350559en_US
dc.identifier.scopus2-s2.0-4444322962en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejvs.2004.06.004
dc.identifier.urihttps://hdl.handle.net/11616/94561
dc.identifier.volume28en_US
dc.identifier.wosWOS:000224042600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofEuropean Journal of Vascular and Endovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterdosteineen_US
dc.subjectischemia/reperfusion injuryen_US
dc.subjectoxidative damageen_US
dc.subjectspinal corden_US
dc.titleErdosteine ameliorates neurological outcome and oxidative stress due to ischemia/reperfusion injury in rabbit spinal corden_US
dc.typeArticleen_US

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