8 Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats

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dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridVardı, Nigar/0000-0003-0576-1696;
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidElbe, Hulya/D-5261-2015
dc.contributor.authorElbe, H.
dc.contributor.authorEsrefoglu, M.
dc.contributor.authorVardi, N.
dc.contributor.authorTaslidere, E.
dc.contributor.authorOzerol, E.
dc.contributor.authorTanbek, K.
dc.date.accessioned2024-08-04T20:41:08Z
dc.date.available2024-08-04T20:41:08Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, effects of melatonin, quercetin and resveratrol on hepatocellular injury in streptozotocin (STZ)-induced experimental diabetes were aimed to be investigated by histological and biochemical methods. Thirty-five male Wistar albino rats were divided into five groups, namely, control, diabetes (STZ 45 mg/kg/single dose/intraperitoneally (ip)), diabetes + melatonin (10 mg/kg/30 days/ip), diabetes + quercetin (25 mg/kg/30 days/ip) and diabetes + resveratrol (10 mg/kg/30 days/ip). Initial and final blood glucose levels and body weights (BWs) were measured. At the end of the experimentation, following routine tissue processing procedure, sections were stained with haematoxylin-eosin (H-E), periodic acid Schiff and Masson's trichrome. Tissue malondialdehyde (MDA) and glutathione (GSH) levels and superoxide dismutase (SOD) and catalase (CAT) activities were examined. The diabetic rats had significantly higher blood glucose levels than those of control rats (p = 0.0001). Mean BWs of diabetic rats were significantly decreased when compared with the control rats (p = 0.0013). Histopathological alterations including cellular glycogen depletion, congestion, sinusoidal dilatation, inflammation and fibrosis were detected in diabetes group. On the other hand, histopathological changes markedly reduced in all of the treatment groups (p = 0.001). Mean tissue MDA level was increased but mean tissue CAT and SOD activities and GSH levels were decreased in the diabetes group. Melatonin, quercetin and resveratrol administered diabetic rats showed an increase in CAT activities and GSH levels and a decrease in MDA levels (p < 0.05, for all). Melatonin, quercetin and resveratrol administrations markedly reduced hepatocellular injury in STZ-induced experimental diabetes.en_US
dc.description.sponsorshipInonu University Scientific Research Foundationen_US
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Research Foundation.en_US
dc.identifier.doi10.1177/0960327114559993
dc.identifier.endpage868en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue9en_US
dc.identifier.pmid26286521en_US
dc.identifier.scopus2-s2.0-84939629332en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage859en_US
dc.identifier.urihttps://doi.org/10.1177/0960327114559993
dc.identifier.urihttps://hdl.handle.net/11616/96934
dc.identifier.volume34en_US
dc.identifier.wosWOS:000360090300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjecthepatic damageen_US
dc.subjectmelatoninen_US
dc.subjectquercetinen_US
dc.subjectresveratrolen_US
dc.title8 Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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