Unveiling the Chemical Constituents and Inhibitory Roles of Extracts from Pinus Pinea L. Nut and Nutshell: A Novel Source for Pharmaceutical Antimicrobials

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dc.contributor.authorUnver, Tuba
dc.contributor.authorGurhan, Ismet
dc.date.accessioned2026-04-04T13:37:44Z
dc.date.available2026-04-04T13:37:44Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractAntibiotic resistance in infectious diseases has been a serious problem for the last century, and scientists have focused on discovering new natural antimicrobial agents. Pinus pinea has been used as a natural pharmacotherapeutic agent with antimutagenic, anticarcinogenic, and high antioxidant properties. In this study, GC-MS and LC-HR/MS were employed to analyze Pinus pinea L. nut and nutshell extracts. DPPH radical scavenging assay was performed to analyze the antioxidant properties of the extracts, but no activity was determined. GC-MS analysis showed that linoleic, oleic, and palmitic acids were the three most dominant fatty acids in nut and nutshell extracts, with ratios between 6.75 % and 47.06 % (v/v). LC-HR/MS revealed that the nutshell methanol extract had a higher phenolic content than other extracts, with vanillic acid (1.4071 mg/g). Antimicrobial activity assays showed that the minimum inhibitory concentrations (MIC) of the extracts varied between 5.94 and 190 mg/mL, and the most significant inhibition was seen in the nutshell methanol extract (MICs: between 5.94 and 47.5 mg/mL). Consequently, the antimicrobial activity of the extracts can be attributed to the dense fatty acids they contain, and the nutshell methanol extract showed the most potent inhibition related to the abundance of phenolic compounds in the extract.
dc.identifier.doi10.1002/cbdv.202401208
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue10
dc.identifier.orcid0000-0001-7017-2447
dc.identifier.orcid0000-0002-8655-2716
dc.identifier.pmid39178285
dc.identifier.scopus2-s2.0-85206397645
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/cbdv.202401208
dc.identifier.urihttps://hdl.handle.net/11616/109997
dc.identifier.volume21
dc.identifier.wosWOS:001340436700026
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectGC-MS and LC-HR/MS
dc.subjectherbal medicine
dc.subjectpharmaceutical antimicrobials
dc.subjectPinus pinea nuts-nutshells
dc.subjecttherapeutic agent
dc.titleUnveiling the Chemical Constituents and Inhibitory Roles of Extracts from Pinus Pinea L. Nut and Nutshell: A Novel Source for Pharmaceutical Antimicrobials
dc.typeArticle

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