Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?
| dc.contributor.author | Akgöl, Gürkan | |
| dc.contributor.author | Ulusoy, Hasan | |
| dc.contributor.author | Telo, Selda | |
| dc.contributor.author | Gülkesen, Arif | |
| dc.contributor.author | Yıldırım, Tülay | |
| dc.contributor.author | Poyraz, Ahmet Kürşad | |
| dc.contributor.author | Kaya, Arzu | |
| dc.date.accessioned | 2021-11-30T16:52:04Z | |
| dc.date.available | 2021-11-30T16:52:04Z | |
| dc.date.issued | 2016 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Abstract: Objectives: This study aims to evaluate serum 4-hydroxynonenal (4-HNE) levels and its clinical and radiological significance in patients with rheumatoid arthritis (RA).Patients and methods: The study included 40 patients (8 males, 32 females; mean age 51.4±11.2 years; range 24 to 72 years) with RA and 30 healthy controls (8 males, 32 females; mean age 53.0±11.7 years; range 24 to 72 years. Serum 4-HNE levels were measured using sandwich enzyme-linked immunosorbent assay method. Patients with disease activity score 28 <=3.2 and >3.2 were allocated into low and high/moderate disease activity groups, respectively. Additionally, patients were divided into two groups as early RA (disease duration <=2 years) and established RA (disease duration >=2 years). Functional disability was evaluated using health assessment questionnaire. Radiographs were scored using the modified Larsen scoring.Results: Serum 4-HNE levels in patients with RA were significantly higher than controls (p=0.001). Serum 4-HNE levels did not correlate with laboratory or clinical parameters of disease activity including erythrocyte sedimentation rate, C-reactive protein, disease activity score 28, and health assessment questionnaire. Serum 4-HNE levels were higher in patients with established RA than patients with early RA (r=0.487, p=0.001). Besides, modified Larsen score which indicates structural damage correlated significantly with serum 4-HNE levels (p=0.001).Conclusion: These results indicate that serum 4-HNE levels may be used as an indicator for structural damage such as erosions in the early stage of RA; however, they are not efficient to monitor disease activity. | en_US |
| dc.identifier.citation | AKGÖL G,ULUSOY H,TELO S,GÜLKESEN A,YILDIRIM T,POYRAZ A. K,KAYA A (2016). Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?. Archives of Rheumatology, 31(1), 76 - 81. | en_US |
| dc.identifier.endpage | 81 | en_US |
| dc.identifier.issn | 2148-5046 | |
| dc.identifier.issn | 2618-6500 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 76 | en_US |
| dc.identifier.trdizinid | 203318 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/43614 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/203318 | |
| dc.identifier.volume | 31 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Archives of Rheumatology | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis? | en_US |
| dc.type | Article | en_US |
