Dose-Dependent Protective Effect of Ivabradine against Ischemia-Reperfusion-Induced Renal Injury in Rats

Basit Öğe Kaydı
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridSarihan, Mehmet Ediz/0000-0002-1266-4213
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.contributor.authorBeytur, Ali
dc.contributor.authorBinbay, Murat
dc.contributor.authorSarihan, M. Ediz
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorGunaydin, M. Orhun
dc.contributor.authorAcet, Ahmet
dc.date.accessioned2024-08-04T20:35:36Z
dc.date.available2024-08-04T20:35:36Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: This study was designed to investigate the dose-dependent protective effect of ivabradine, a specific inhibitor of the cardiac sinoatrial node, on renal ischemia-reperfusion (I/R) injury in rats. Methods: Rats were divided into six groups: group 1, control; group 2, I/R (60 min ischemia followed by 24 h reperfusion); groups 3 and 4, 0.6-6 mg/kg ivabradine; and groups 5 and 6, sham+0.6-6 mg/kg ivabradine. At the end of the study, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase contents were assayed in the kidney tissues; serum blood levels of urea nitrogen (BUN), creatinine (Cr) and albumin also were determined. Results: Tissue MDA levels were found to be significantly higher in the I/R group, whereas SOD and CAT levels were lower when compared to the control group. Ivabradine (0.6 mg/kg) treatment reduced the MDA levels and elevated the SOD and CAT enzyme activity. Treatment with a dose of 6 mg/kg ivabradine further increased MDA levels and did not ameliorate SOD or CAT activities. Serum levels of BUN and Cr were significantly higher in the I/R group. I/R+0.6 mg ivabradine reduced the elevated BUN and Cr levels. Conclusion:This study indicates that ivabradine exerts a dose-dependent response beyond heart rate reduction against renal I/R injury. Copyright (C) 2011 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000330501
dc.identifier.endpage119en_US
dc.identifier.issn1420-4096
dc.identifier.issn1423-0143
dc.identifier.issue2en_US
dc.identifier.pmid22056748en_US
dc.identifier.scopus2-s2.0-80155212934en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.1159/000330501
dc.identifier.urihttps://hdl.handle.net/11616/95474
dc.identifier.volume35en_US
dc.identifier.wosWOS:000301394400039en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofKidney & Blood Pressure Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectIvabradineen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.subjectRenal ischemiaen_US
dc.titleDose-Dependent Protective Effect of Ivabradine against Ischemia-Reperfusion-Induced Renal Injury in Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu