Candida albicans outbreak associated with total parenteral nutrition in the neonatal unit
| dc.authorid | 101949 | en_US |
| dc.contributor.author | Güdücüoğlu, Hüseyin | |
| dc.contributor.author | Gültepe, Bilge Sümbül | |
| dc.contributor.author | Otlu, Barış | |
| dc.contributor.author | Bektaş, Hava | |
| dc.contributor.author | Yıldırım, Özge | |
| dc.contributor.author | Tuncer, Oğuz | |
| dc.contributor.author | Berktaş, Mustafa | |
| dc.date.accessioned | 2017-07-10T07:33:50Z | |
| dc.date.available | 2017-07-10T07:33:50Z | |
| dc.date.issued | 2016 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Background: The most frequently isolated fungi in patients using TPN belongs to the Candida genus. Various infections including venous catheter infections, fungemia, endocarditis and ophthalmitis may be encountered. Objective: Upon growth of Candida in the blood cultures from the pediatric (neonatal) unit of our hospital, a surveillance was performed in this unit and involving the health care workers. Clonal relationships of the isolates were investigated with molecular tests. Methods: Blood samples obtained from the patients in pediatric neonatal unit were studied with automatized blood culture [BacT/Alert (Bio Mérioux, France)]. Yeast isolates from environmental surveillance cultures (TPN solutions, hands of healthcare personnel, étagère, etc) and patients were identified as C. albicans with conventional methods and ID 32 C and ATBTM Fungus 3 (Biomerieux, France) kits. Clonal similarity was determined by using AP-PCR as initial method and we have also typified all strains by the method of REP-PCR (diversilab system,bioMérieux). Finally; Pulsed Field Gel Electrophoresis (PFGE) was used for confirmation. Results: C. albicans was isolated in blood cultures of seven patients. Similar antifungal susceptibility patterns were observed in all isolates. AP-PCR and REP-PCR showed that the C. albicans isolates grown in the TPN solution and from the patients’ blood cultures were clonally same strains. PFGE analysis further confirmed this clonality. Conclusion: According to results of the molecular methods, we thought that a C. albicans outbreak had occurred in the neonatal pediatric unit, due to contamination of TPN solution. | en_US |
| dc.identifier.citation | Güdücüoğlu, H. Gültepe, B. S. Otlu, B. Bektaş, H. Yıldırım, Ö. Tuncer, O. Berktaş, M. (2016). Candida albicans outbreak associated with total parenteral nutrition in the neonatal unit. Indian Journal of Medical Microbiology, 34(2), 202–207. | en_US |
| dc.identifier.doi | 10.4103/0255-0857.180303 | en_US |
| dc.identifier.endpage | 207 | en_US |
| dc.identifier.issn | 0255-0857 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 202 | en_US |
| dc.identifier.uri | http://www.ijmm.org/text.asp?2016/34/2/202/180303 | |
| dc.identifier.uri | https://hdl.handle.net/11616/7351 | |
| dc.identifier.volume | 34 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Indian Journal of Medical Microbiology | en_US |
| dc.relation.ispartof | Indian Journal of Medical Microbiology | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Candida albicans | en_US |
| dc.subject | Fungal infection | en_US |
| dc.subject | Neonatal unit | en_US |
| dc.subject | Parenteral nutrition | en_US |
| dc.title | Candida albicans outbreak associated with total parenteral nutrition in the neonatal unit | en_US |
| dc.type | Article | en_US |
