Adrenomedullin and nitrite levels in children with dilated cardiomyopathy

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dc.authoridBalat, Ayse/0000-0002-8904-1348
dc.authoridKILINÇ, Metin/0000-0003-1385-6492
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidKILINÇ, Metin/AAG-6503-2020
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorKilinç, M
dc.contributor.authorBalat, A
dc.contributor.authorÇekmen, M
dc.contributor.authorYürekli, M
dc.contributor.authorYilmaz, K
dc.contributor.authorSahinöz, S
dc.date.accessioned2024-08-04T20:13:26Z
dc.date.available2024-08-04T20:13:26Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDilated cardiomyopathy (DCM) is an important cause of chronic congestive cardiac failure in children. In patients with idiopathic DCM, endothelium vasomotor function is disturbed. There are many studies on the roles of nitric oxide (NO) and adrenomedullin (AM) in adult patients with DCM. However, to our knowledge, no studies have investigated the level of AM and NO in children with idiopathic DCM. We determined plasma and urinary AM and total nitrite concentrations in children with idiopathic DCM and investigated the correlation between these and other clinical and laboratory findings. Eleven patients with DCM, ranging in age from 5 month to 14 years, were compared to 10 healthy age- and sex-matched controls. Plasma (pmol/ml) and urinary (pmol/mg creatinine) AM levels were significantly lower than in the healthy controls (19.55 +/- 2.36 vs 51.61 +/- 7.22 and 28.29 +/- 20.66 vs 68.87 +/- 40.23, respectively; p < 0.001). Plasma and urinary AM levels were negatively correlated with ejection fraction (EF) and fractional shortening (FS). The plasma (Mmol/L) and urinary nitrite levels (Mmol/mg creatinine) were not different between patients and controls [50.90 +/- 17.50 vs 53.40 +/- 26.05 (p > 0.05) and 1.98 +/- 1.24 vs 2.75 +/- 1.68 (p > 0.05), respectively]. In our study, the first to analyze AM and nitrite levels in children with DCM, plasma and urinary AM levels were found to be decreased. A possible explanation for this reduction could be depletion of the viable myocyte population. However, this hypothesis must be clarified by further studies.en_US
dc.identifier.doi10.1007/s00246-002-0352-8
dc.identifier.endpage385en_US
dc.identifier.issn0172-0643
dc.identifier.issue4en_US
dc.identifier.pmid12522650en_US
dc.identifier.scopus2-s2.0-0042470915en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-002-0352-8
dc.identifier.urihttps://hdl.handle.net/11616/93597
dc.identifier.volume24en_US
dc.identifier.wosWOS:000183913100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectdilated cardiomyopathyen_US
dc.subjectchildrenen_US
dc.subjectnitric oxideen_US
dc.titleAdrenomedullin and nitrite levels in children with dilated cardiomyopathyen_US
dc.typeArticleen_US

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