Leukapheresis Treatment in Elderly Acute Leukemia Patients with Hyperleukocytosis: A Single Center Experience

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dc.authoridBERBER, Ilhami/0000-0003-3312-8476
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authorwosidBERBER, Ilhami/ABI-6231-2020
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidKAYA, Emin/W-2951-2017
dc.contributor.authorBerber, Ilhami
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorNizam, Ilknur
dc.contributor.authorKoroglu, Mustafa
dc.date.accessioned2024-08-04T20:41:26Z
dc.date.available2024-08-04T20:41:26Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Leukapheresis is an invasive treatment modality used for hyperleukocytosis. Various drugs and fluids are used during the leukapheresis. Aging itself and associated factors such as increased comorbidity, decreased tolerance to drugs, increased drug toxicity give rise to the application of other treatment modalities in elderly patients. Treatment of acute leukemia in the elderly differs from young patients. Consequently, we assumed that outcome, effectiveness, and side effects of leukapheresis treatment used for acute leukemia patients with hyperleukocytosis may be different in elderly compared to younger patients. Methods: We retrospectively evaluated a total of 39 patients. Eighteen patients were 65 years and older. Indications for leukapheresis were determined as symptoms of leukostasis and prophylaxis. Acid citrate dextrose-A, calcium gluconate, and plasma were used during the leukapheresis. Age, sex, diagnosis, count, and indications of leukapheresis procedures, leukocyte count, and lactate dehydrogenase level were analyzed at the onset of and after leukapheresis; side effects, causes of death, early and total mortality rates were also analyzed. We compared the two groups with regard to effectiveness, clinical outcomes, and side effects. Results: There were no statistically significant differences between the two groups with respect to sex, diagnosis, initial leukocyte count, lactate dehydrogenase level, number of leukapheresis procedures, rates of side effects, or early and total mortality (P > 0.05). Leukapheresis treatment was effective in both groups (P < 0.05) and no significant difference was found in its effectiveness between two groups ( P> 0.05). Conclusion: Leukapheresis is an effective and safe treatment modality in elderly acute leukemia patients with hyperleukocytosis. (C) 2015 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/jca.21402
dc.identifier.endpage58en_US
dc.identifier.issn0733-2459
dc.identifier.issn1098-1101
dc.identifier.issue1en_US
dc.identifier.pmid26011305en_US
dc.identifier.scopus2-s2.0-84954400010en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1002/jca.21402
dc.identifier.urihttps://hdl.handle.net/11616/97122
dc.identifier.volume31en_US
dc.identifier.wosWOS:000368277000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Apheresisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectleukapheresisen_US
dc.subjecthyperleukocytosisen_US
dc.subjectacute leukemiaen_US
dc.subjectelderly patientsen_US
dc.titleLeukapheresis Treatment in Elderly Acute Leukemia Patients with Hyperleukocytosis: A Single Center Experienceen_US
dc.typeArticleen_US

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