Genotoxic effects of sulfur dioxide in human lymphocytes

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dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authoridÖnal, Yunus/0000-0001-6342-6816
dc.authorwosidÜren, Nihal/F-8458-2018
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.authorwosidÖnal, Yunus/E-7170-2018
dc.contributor.authorUren, Nihal
dc.contributor.authorYuksel, Sengul
dc.contributor.authorOnal, Yunus
dc.date.accessioned2024-08-04T20:39:40Z
dc.date.available2024-08-04T20:39:40Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSulfur dioxide (SO2), which is used as food preservative in apricot sulfurization and several fabricated foods, is a common air pollutant. The aim of this study was to reveal the possible genotoxic effects of SO2 using in vitro human lymphocytes. The different endpoints of genotoxicity: sister chromatid exchange (SCE), micronuclei (MN) tests and cell growth kinetics such as mitotic index (MI) and replication index (RI) were studied. The cells were treated with 0.1, 0.5 and 1.0 ppm concentrations of SO2. It was shown that SO2 caused significant increases in the frequency of SCE and MN in the middle and high dosage groups and also induced mitotic delays and decreased MI and RI. In conclusion, the results have confirmed that SO2 has potent mutagenicity and it can cause genetic damage leading to a malignancy.en_US
dc.description.sponsorshipInonu University Research Fund [2008/69]en_US
dc.description.sponsorshipThis study was funded by Inonu University Research Fund (2008/69).en_US
dc.identifier.doi10.1177/0748233712457441
dc.identifier.endpage315en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue4en_US
dc.identifier.pmid22903179en_US
dc.identifier.scopus2-s2.0-84899829377en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712457441
dc.identifier.urihttps://hdl.handle.net/11616/96432
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335087800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgenotoxicityen_US
dc.subjectsister chromatid exchangeen_US
dc.subjectSulfur dioxideen_US
dc.subjectmicronucleusen_US
dc.titleGenotoxic effects of sulfur dioxide in human lymphocytesen_US
dc.typeArticleen_US

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