Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter pylori

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dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorMehmet, N
dc.contributor.authorRefik, M
dc.contributor.authorHarputluoglu, M
dc.contributor.authorErsoy, Y
dc.contributor.authorAydin, NE
dc.contributor.authorYildirim, B
dc.date.accessioned2024-08-04T20:15:11Z
dc.date.available2024-08-04T20:15:11Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis case control study presents data on the concentrations of nitrite and nitrate and a variety of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-2R (IL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor TNF-alpha in gastric fluid and serum. Patients with gastritis, gastric ulcer and gastric cancer are studied and grouped according to infection by Helicobacter pylori. The 208 patients who underwent tipper gastrointestinal endoscopic examination were classified as follows; H. pylori-positive gastritis (n=32), H. pylori-negative gastritis (n=32), H. pylori-positive ulcers (n=34), H. pylori-negative ulcers (n=34), 43 patients with H. pylori-positive gastric cancer in addition to 33 H. pylori-negative healthy control individuals. Gastric fluids and blood samples were taken concomitantly. Cytokines and nitrite and nitrate determinations were attempted as soon as possible after collection of the samples. Nitrite and nitrate levels of serum and gastric fluids of H. pylori-positive gastritis and ulcers were higher than H. pylori-negative gastritis and ulcers. The concentrations of total nitrite and nitrate and cytokines (TNF-alpha IL-2R, IL-6, and IL-8) in gastric fluids and sera of H. pylori-positive gastric cancer patients were higher than H. pylori-negative control groups. IL-1beta level was significantly elevated in gastric fluid of infected cancer patients but not in serum. Taken together, the results suggest that an increase in cytokine-NO combination in gastric mucosa previously reported by many studies is not restricted to local infected gastric tissue but also detected in gastric fluid and sera of H. pylori-positive subjects and may have an important role in the pathogenesis and development of common gastric diseases.en_US
dc.identifier.endpage148en_US
dc.identifier.issn1121-7138
dc.identifier.issue2en_US
dc.identifier.pmid15164624en_US
dc.identifier.scopus2-s2.0-3042576364en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://hdl.handle.net/11616/94216
dc.identifier.volume27en_US
dc.identifier.wosWOS:000221471900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLuigi Ponzio E Figlioen_US
dc.relation.ispartofMicrobiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectcytokinesen_US
dc.subjectnitrateen_US
dc.subjectnitric oxideen_US
dc.subjectgastritisen_US
dc.subjectgastric ulceren_US
dc.subjectgastric canceren_US
dc.titleSerum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter pylorien_US
dc.typeArticleen_US

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