Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

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dc.authoridTANYILDIZI, SADETTIN/0000-0001-7012-5392
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.contributor.authorCiftci, Osman
dc.contributor.authorTanyildizi, Sadettin
dc.contributor.authorGodekmerdan, Ahmet
dc.date.accessioned2024-08-04T20:32:17Z
dc.date.available2024-08-04T20:32:17Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMaterial and methods: For this purpose, 128 3-4-month-old Wistar albino rats with 280-310 g body weights were used. The 2 mu g/kg dose of 2,3,7,8-TCDD and 100 mg/kg dose of curcumin were dissolved in corn oil and orally given to the rats found in the experimental and control groups. Then, the serum samples were taken from all rats at 15, 30, 45 and 60 days to analyzed for the determination of TNF-alpha, IFN-gamma, IL-12 and IL-13 levels by ELISA method. The data of body weight gain was measured at 15, 30, 45 and 60 days. Results: The results indicated that 2,3,7,8-TCDD caused a significant increase (p < 0.05) in serum TNF-alpha level. However, it caused significant (p < 0.05) decreases in the levels of IFN-gamma, IL-12 and IL-13 in rats. On the contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats. Additionally, TCDD caused significant (P < 0.01) reductions in the body weight gain. However, curcumin reversed this effect of TCDD. Conclusion: 2,3,7,8-TCDD significantly suppressed the humoral immunity and body weight gain in rats at doses of 2 mu g/kg. However curcumin, which was found in some plants, eliminated the effect of TCDD on immune system and body weight when it was given together with 2,3,7,8-TCDD. It is thought that this effect may have occurred via curcumin and TCDD binding aryl hydrocarbon receptor (AhR) competitively.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technical Research Council of the Turkish. Republic) [106 0 815]en_US
dc.description.sponsorshipThe authors thank TUBITAK (Scientific and Technical Research Council of the Turkish. Republic) for their financial support (grant 106 0 815).; Declaration of interest: This study was concluded by funding from TUBITAK grant 106 0 815.en_US
dc.identifier.doi10.3109/08923970903164318
dc.identifier.endpage104en_US
dc.identifier.issn0892-3973
dc.identifier.issue1en_US
dc.identifier.pmid19821784en_US
dc.identifier.scopus2-s2.0-77249134580en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.3109/08923970903164318
dc.identifier.urihttps://hdl.handle.net/11616/94983
dc.identifier.volume32en_US
dc.identifier.wosWOS:000274909100013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofImmunopharmacology and Immunotoxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,3,7,8-TCDDen_US
dc.subjectcurcuminen_US
dc.subjectcytokineen_US
dc.subjectbody weighten_US
dc.titleProtective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)en_US
dc.typeArticleen_US

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