Adrenomedullin and nitrite levels in children with primary nocturnal enuresis

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dc.authoridBalat, Ayse/0000-0002-8904-1348
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridAnarat, Ali/0000-0001-8000-9213
dc.authoridugras, meltem/0000-0001-9634-1229
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidAnarat, Ali/F-1228-2013
dc.authorwosid, mehmet/AAG-6430-2020
dc.authorwosidKAPLAN, MEHMET/AAA-9808-2020
dc.contributor.authorBalat, AE
dc.contributor.authorÇekmen, M
dc.contributor.authorYürekli, M
dc.contributor.authorGül, AK
dc.contributor.authorÖzbek, E
dc.contributor.authorKorkut, M
dc.contributor.authorTarakçioglu, M
dc.date.accessioned2024-08-04T20:13:11Z
dc.date.available2024-08-04T20:13:11Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPrimary nocturnal enuresis (PNE) is the most common type of nocturnal enuresis in children, but its etiology remains unclear. Recent studies indicated the differences in urinary electrolytes in enuretic children, and stressed the existence of a renal tubular maturation defect. In this study, 30 children (aged 6-12 years) with PNE were investigated in comparison with 18 healthy controls. We evaluated plasma antidiuretic hormone, electrolytes, 24-h urine volume, osmolarity, and urinary electrolytes. Unlike other studies, we firstly assessed the plasma and urinary adrenomedullin (AM) and total nitrite levels, a stable product of nitric oxide (NO), and investigated their relationship with urinary electrolytes. The plasma AM and total nitrite levels were significantly lower than controls. Urine volume (24-h) and potassium excretion were higher than in controls. However, 24-h urinary osmolarity and excretion of AM were significantly lower than in controls. Our results indicate that there may be a problem in renal regulation of potassium in children with PNE. Although decreased levels of AM and total nitrite may be a compensatory response to abnormal potassium and water excretion, further investigations are required to exclude whether the renal synthesis of AM and NO are also deficient in these children.en_US
dc.identifier.doi10.1007/s00467-002-0922-2
dc.identifier.endpage624en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue8en_US
dc.identifier.pmid12185469en_US
dc.identifier.scopus2-s2.0-0036951975en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage620en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-002-0922-2
dc.identifier.urihttps://hdl.handle.net/11616/93457
dc.identifier.volume17en_US
dc.identifier.wosWOS:000177601500009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectenuresisen_US
dc.subjectnitric oxideen_US
dc.titleAdrenomedullin and nitrite levels in children with primary nocturnal enuresisen_US
dc.typeArticleen_US

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