Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial

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dc.authoridOtlu, Onder/0000-0001-5958-7609
dc.authoridsabancı, arife/0000-0002-0956-1600
dc.authorwosidOtlu, Onder/W-3887-2018
dc.authorwosidsabancı, arife/ABG-9792-2020
dc.contributor.authorSeydanur Dengizek, Eltas
dc.contributor.authorSerkan, Dundar
dc.contributor.authorAbubekir, Eltas
dc.contributor.authorAysun Bay, Karabulut
dc.contributor.authorOnder, Otlu
dc.contributor.authorArife, Cicek
dc.date.accessioned2024-08-04T20:45:41Z
dc.date.available2024-08-04T20:45:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-beta) levels were evaluated from saliva samples. Results: Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-beta levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05). Conclusion: The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.en_US
dc.description.sponsorshipScientific Research Project Fund of Inonu University [2011/73]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Inonu University (2011/73).en_US
dc.identifier.doi10.1590/1678-7757-2018-0108
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.pmid30673028en_US
dc.identifier.scopus2-s2.0-85060387406en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1590/1678-7757-2018-0108
dc.identifier.urihttps://hdl.handle.net/11616/98622
dc.identifier.volume27en_US
dc.identifier.wosWOS:000456079700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo Fac Odontologia Bauruen_US
dc.relation.ispartofJournal of Applied Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic periodontitisen_US
dc.subjectInflammationen_US
dc.subjectOzoneen_US
dc.subjectPeriodontal treatmenten_US
dc.subjectTGF-betaen_US
dc.titleEvaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trialen_US
dc.typeArticleen_US

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