The effect of resveratrol in experimental cataract model formed by sodium selenite

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dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.contributor.authorDoganay, S
dc.contributor.authorBorazan, M
dc.contributor.authorIraz, M
dc.contributor.authorCigremis, Y
dc.date.accessioned2024-08-04T20:15:17Z
dc.date.available2024-08-04T20:15:17Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose : To investigate if resveratrol can prevent sodium selenite-induced experimental cataract model in rats. Methods : Forty-eight Spraque-Dawley rat pups were divided into 3 treatment groups: (1) normal saline-% 5 ethanol injected i.p. on postpatum day 10; (2) Na selenite (30 nmol/g body wt) injected s.c on day 10; (3) Na selenite s.c on day 10 + resveratrol (40 mg/kg) i.p on days 10-13. On day 21, cataract development was graded by slit-lamp examination and photography. Encapsulated lenses and erythrocytes were analyzed for reduced glutathione (GSH) and malondialdehyde (MDA), a marker of lipid peroxidation. Lenses were also analyzed for total nitrite (TN). Results : All control lenses in group 1 were clear. In group 2, all rats developed cataracts (grade 3-grade 6), whereas in group 3, only 9 of 16 rats developed cataracts (grade 2-grade 3). The difference of cataract frequency between groups 2 and 3 was statistically significant (p p < 0.05). Group 3 lenses and erythrocytes had higher mean GSH and lower mean MDA levels than those in group 2 (p < 0.05). TN was highest in group 3 and lowest in group 1 (p < 0.05). Conclusions: Resveratrol suppressed selenite-induced oxidative stress and cataract formation in rats. This protective effect was supported by higher GSH and lower MDA in lens and erythrocytes. The presence of oxidative stress in selenite cataract development and its prevention by resveratrol support the possibility that high natural consumption of resveratrol in food can help prevent human senile cataract.en_US
dc.identifier.doi10.1080/02713680500514685
dc.identifier.endpage153en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue2en_US
dc.identifier.pmid16500765en_US
dc.identifier.scopus2-s2.0-33644614553en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.1080/02713680500514685
dc.identifier.urihttps://hdl.handle.net/11616/94292
dc.identifier.volume31en_US
dc.identifier.wosWOS:000235553100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidanten_US
dc.subjectresveratrolen_US
dc.subjectselenite cataracten_US
dc.subjectsenile cataracten_US
dc.titleThe effect of resveratrol in experimental cataract model formed by sodium seleniteen_US
dc.typeArticleen_US

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