Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridbilgic, yılmaz/0000-0002-2169-5548
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorBilgic, Yilmaz
dc.contributor.authorAkbulut, Sami
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorOzhan, Onural
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:45:26Z
dc.date.available2024-08-04T20:45:26Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the protective effect of dexpanthenol (Dexp) against cisplatin (Cis)-induced hepatotoxicity. Thirty-two Sprague Dawley rats were divided into four groups: Control group (n=8), Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp), Cis group (n=8, 7 mg/kg/ip/single dose Cis) and Cis+Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp +7 mg/kg/ip/single dose Cis). MDA, CAT, GSH, GSH-Px, TOS, TAS, OSI, Total Nitrit, IL-1 beta, IL-6 and TNF-alpha levels were analyzed in liver tissue samples. After paraffinization of liver tissue samples, histopathological (congestion, loss of glycogen, number of Kupffer cells) and immunohistochemical (caspase-3 expression) parameters were assessed on the paraffinized liver sections. GSH, TAS, TOS, OSI, Tot Nit, L-Arginine, ADMA and SDMA levels were measured in the serum samples. Statistically significant differences were found between the groups in terms of all liver tissue biochemical parameters, with the exception of IL-1 beta and TNF-alpha levels. GSH, CAT, GSH-Px, TAS and Tot Nit levels were significantly higher in the Cis+Dexp group compared to the Cis group, whereas MDA, TOS, OSI and IL-6 levels were higher in the Cis group. Similarly, serum GSH, TAS, Tot Nit levels were higher in the Cis+Dexp group whereas TOS, L-Arginine, ADMA and SDMA levels were higher in Cis group. There were statistically significant differences between Control and Cis groups in terms of congestion increase, increase of glycogen loss, increase of Kupffer cell number and increase of caspase-3 expression (P<0.001). There was a statistically significant difference between the Cis and the Cis+Dexp groups in terms of histopathologic parameters, with the exception of congestion (P<0.001). To conclude, histopathological, immunohistochemical, and biochemical results of this study demonstrated that Dexp has a protective effect against Cis-induced hepatotoxicity.en_US
dc.description.sponsorshipInonu University Scientific Research Project Coordination Unit [2016/179]en_US
dc.description.sponsorshipThe present study was supported by the Inonu University Scientific Research Project Coordination Unit (grant no. 2016/179).en_US
dc.identifier.doi10.3892/etm.2018.6683
dc.identifier.endpage4057en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue5en_US
dc.identifier.pmid30402149en_US
dc.identifier.scopus2-s2.0-85053855999en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage4049en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2018.6683
dc.identifier.urihttps://hdl.handle.net/11616/98477
dc.identifier.volume16en_US
dc.identifier.wosWOS:000448431900040en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcisplatinen_US
dc.subjecthepatotoxicityen_US
dc.subjectdexpanthenolen_US
dc.subjectantioxidant potentialen_US
dc.titleProtective effect of dexpanthenol against cisplatin-induced hepatotoxicityen_US
dc.typeArticleen_US

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