Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
| dc.contributor.author | Kaya, Yasin Emre | |
| dc.contributor.author | Karaarslan, Numan | |
| dc.contributor.author | Yilmaz, İbrahim | |
| dc.contributor.author | Yasar Sirin, Duygu | |
| dc.contributor.author | Yaman, Onur | |
| dc.contributor.author | Ozbek, Hanefi | |
| dc.contributor.author | Ates, Ozkan | |
| dc.date.accessioned | 2022-03-09T09:44:35Z | |
| dc.date.available | 2022-03-09T09:44:35Z | |
| dc.date.issued | 2020 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P 0.05). Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment. | en_US |
| dc.identifier.citation | Emre Kaya, Y., Karaarslan, N., Yilmaz, I., Yasar Sirin, D., Yaman, O., Ozbek, H., & Ates, O. (2021). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures . Annals of Medical Research | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/54932 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures | en_US |
| dc.type | Article | en_US |
