Genotyping of rifampin-resistant Mycobacterium tuberculosis isolates from western Turkey

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.contributor.authorCavusoglu, C
dc.contributor.authorDurmaz, R
dc.contributor.authorBilgic, A
dc.contributor.authorGunal, S
dc.date.accessioned2024-08-04T20:14:43Z
dc.date.available2024-08-04T20:14:43Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Although the rate of multiple drug resistance is high, there is no published data on the transmission rate of drug-resistant strains of Mycobacterium tuberculosis in the Aegean region of western Turkey that are based on molecular methods. Methods: IS6110 and pTBN12 restriction fragment length polymorphism (RFLP) methods were used for typing M. tuberculosis strains isolated from 26 sputum samples from 26 patients. Results: Nineteen of the rifampin-resistant isolates (73.1%) contained 6 to 11 copies of IS6110. Eighteen different IS6110 DNA fingerprint patterns were observed in the 26 rifampin-resistant isolates. Twenty-three of the 26 rifampin-resistant isolates were also resistant to isoniazid. When evaluated together, both methods yielded 21 (80.9%) different banding patterns and the level of clustering was 34.6%. The average number per pattern was 1.23 (26/21). Conclusions: IS6110 fingerprinting suggests that the rifampin-resistant isolates obtained from the Aegean region had a relatively high clustering rate and were clonally related. These findings showed that the rifampin-resistant isolates are actively transmitted between patients. Urgent measures should be taken to prevent the spread of these resistant strains.en_US
dc.identifier.doi10.5144/0256-4947.2004.102
dc.identifier.endpage105en_US
dc.identifier.issn0256-4947
dc.identifier.issn1319-9226
dc.identifier.issue2en_US
dc.identifier.pmid15323270en_US
dc.identifier.scopus2-s2.0-1842840044en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage102en_US
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2004.102
dc.identifier.urihttps://hdl.handle.net/11616/93918
dc.identifier.volume24en_US
dc.identifier.wosWOS:000220852700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherK Faisal Spec Hosp Res Centreen_US
dc.relation.ispartofAnnals of Saudi Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectmultidrug-resistant tuberculosisen_US
dc.subjectmultiple drug resistanceen_US
dc.subjectDNA fingerprintingen_US
dc.subjectrifampinen_US
dc.subjectTurkeyen_US
dc.titleGenotyping of rifampin-resistant Mycobacterium tuberculosis isolates from western Turkeyen_US
dc.typeArticleen_US

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