Sedation with Propofol and Propofol-Ketamine (Ketofol) in Flexible Bronchoscopy: A Randomized, Double-Blind, Prospective Study

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dc.authoridGulcek, İlham/0000-0001-6204-455X
dc.authorwosidGulcek, İlham/HHS-7311-2022
dc.contributor.authorUlutas, H.
dc.contributor.authorUcar, M.
dc.contributor.authorCelik, M. R.
dc.contributor.authorAgar, M.
dc.contributor.authorGulcek, I
dc.date.accessioned2024-08-04T20:54:58Z
dc.date.available2024-08-04T20:54:58Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground:The flexible bronchoscopy procedure, which is performed in awake conditions or under local anesthesia, is a difficult and complicated procedure for patients and physicians. Propofol is a fast-acting sedative-hypnotic anesthetic with a rapid return. Ketamine hydrochloride is a fast-acting general anesthetic producing an anesthetic state characterized by deep analgesia, normal pharyngeal, and laryngeal reflexes.Materials and Method:The study was planned in a randomized, prospective, and double-blind design. The drug(s) administered by the anesthesiologist was not known to the bronchoscopist and the patient. A total of 64 cases were included in the study (34/propofol, 30/ketamine-propofol (ketofol) group). Group propofol received 0.1 mL/kg propofol, and group ketofol received 0.1 mL/kg ketofol intravenously over approximately 30 seconds. Vital signs, non-invasive blood pressure, peripheral oxygen saturation, and pulse values of all cases were measured three times and were recorded just before the start of the procedure, after entering the trachea, and after the procedure was terminated. The Visual Analogue Scale (VAS) and The Ramsay scoring were additionally used in the present study.Results:Statistically significant differences were detected between the groups in terms of blood pressure and heart rates. Statistically significant differences were detected between the two groups according to The VAS scoring and additional dose requirement.Conclusion:It must be noted that flexible bronchoscopy procedures, which are performed with local anesthesia by both the patient and the physician with a high degree of difficulty, especially combined drugs to be applied with anesthesia support, are more effective/comfortable/reliable, and have fewer complications and higher tolerability if there are no contraindications.en_US
dc.identifier.doi10.4103/njcp.njcp_245_23
dc.identifier.endpage1823en_US
dc.identifier.issn1119-3077
dc.identifier.issn2229-7731
dc.identifier.issue12en_US
dc.identifier.pmid38158347en_US
dc.identifier.scopus2-s2.0-85181414696en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1817en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_245_23
dc.identifier.urihttps://hdl.handle.net/11616/101753
dc.identifier.volume26en_US
dc.identifier.wosWOS:001134313000014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlexible bronchoscopyen_US
dc.subjectpropofolen_US
dc.subjectketofolen_US
dc.subjectVAS scoringen_US
dc.subjectramsay scoringen_US
dc.titleSedation with Propofol and Propofol-Ketamine (Ketofol) in Flexible Bronchoscopy: A Randomized, Double-Blind, Prospective Studyen_US
dc.typeArticleen_US

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