Circulating adrenomedullin levels in ankylosing spondylitis and Familial Mediterranean Fever

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidKarakurt, Feridun/KHY-4589-2024
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorUreten, Kemal
dc.contributor.authorOzbek, Mustafa
dc.contributor.authorOzturk, Mehmet Akif
dc.contributor.authorDogru, Ilker
dc.contributor.authorDogru, Arzu
dc.contributor.authorYurekli, Muhittin
dc.contributor.authorKarakurt, Feridun
dc.date.accessioned2024-08-04T20:30:47Z
dc.date.available2024-08-04T20:30:47Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Adrenomedullin (AM) is a 52-amino acid peptide with vasorelaxant properties. Apart from its roles on vascular tonus, AM can also contribute to inflammatory events. Plasma AM levels were elevated in connective tissue diseases and vasculitic disorders. Ankylosing spondylitis (AS) is a chronic inflammatory disease of the spine initiating in the sacroiliac joints. Familial Mediterranean Fever (FMF) is a hereditary disorder characterized by self-limiting acute attacks of fever and the presence of sustained subclinical inflammation in the attack-free periods. In this study, we investigated plasma AM levels in patients with AS and patients with FMF. Methods: Twenty AS patients with active disease manifestations (mean age: 41.6 +/- 10.9 years, female/male: 7/13), 28 FMF patients with acute attack (mean age: 27.4 +/- 10.7 years, female/male: 17/11), and 26 healthy controls (mean age: 39.9 +/- 5.5 years, female/male: 16/10) were enrolled in this study. AM levels were also measured in 11 FMF patients 2 months after the cessation of their attacks. AM levels of those 11 patients during their FMF attacks and attack-free periods were also compared. Results: Median plasma AM levels were 23.86 (17.24-40.09) pmol/mL, 27.33 (17.24-38.52) pmol/mL, and 26.11 (17.05-37.42) pmol/mL in AS patients, FMF patients with acute attack, and healthy controls, respectively (p > 0.05). AM levels were also similar in the attack-free periods of FMF patients [26.35 (24.35-34.14) pmol/mL]. There was no correlation between plasma AM levels and C-reactive protein, or between plasma AM levels and erythrocyte sedimentation rate. Conclusions: AM does not seem to have any role in the pathogenesis of AS and FMF. Previous reports of elevated levels of AM in connective tissue disorders and vasculitic diseases are probably disease specific, and AM does not seem to be a common component of inflammatory rheumatic disorders. (C) 2008 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.jbspin.2007.09.011
dc.identifier.endpage298en_US
dc.identifier.issn1297-319X
dc.identifier.issn1778-7254
dc.identifier.issue3en_US
dc.identifier.pmid18394945en_US
dc.identifier.scopus2-s2.0-42749096767en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://doi.org/10.1016/j.jbspin.2007.09.011
dc.identifier.urihttps://hdl.handle.net/11616/94517
dc.identifier.volume75en_US
dc.identifier.wosWOS:000256175200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofJoint Bone Spineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectinflammationen_US
dc.subjectankylosing spondylitisen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.titleCirculating adrenomedullin levels in ankylosing spondylitis and Familial Mediterranean Feveren_US
dc.typeArticleen_US

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