Effect of caffeic acid phenethyl ester on cartilage in experimental osteoarthritis

Basit Öğe Kaydı
dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidElmali, Nurzat/A-1017-2014
dc.contributor.authorElmali, N
dc.contributor.authorAvan, I
dc.contributor.authorTürköz, Y
dc.contributor.authorMizrak, B
dc.contributor.authorGermen, B
dc.contributor.authorBora, A
dc.date.accessioned2024-08-04T20:13:08Z
dc.date.available2024-08-04T20:13:08Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractActivation of nuclear factor kappa B (NF-kappaB) in synovial cells is seen in RA and OA patients. Caffeic acid phenethyl ester (CAPE) is a specific and potent inhibitor of NF-kappaB. We aimed to determine the in vivo effects of intra-articular injections of CAPE on cartilage in an experimental rabbit osteoarthritis (OA) model. Two groups of six New Zealand white rabbits underwent unilateral anterior cruciate ligament transection (ACLT). Four weeks after ACLT, the test group was injected with 150 mug/kg CAPE in 0.5% ethanol once daily for 2 weeks and the control group was injected the same amount of 0.5% ethanol intra-articularly. All rabbits were killed 2 weeks after the last injection, and cartilage tissue was evaluated morphologically. A histological score totaling 7 points was determined for each knee. The CAPE group showed significantly decreased cartilage destruction and reduced loss of matrix proteoglycans. The histological score for cartilage tissue was significantly better in the CAPE group than in the control group (3.0 +/- 0.25 vs 5.3 +/- 0.55, P=0.005). This study suggests that intraarticular injection of CAPE may protect cartilage against the development of experimentally induced OA.en_US
dc.identifier.doi10.1007/s00296-002-0232-9
dc.identifier.endpage226en_US
dc.identifier.issn0172-8172
dc.identifier.issue6en_US
dc.identifier.pmid12426659en_US
dc.identifier.scopus2-s2.0-0036430272en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-002-0232-9
dc.identifier.urihttps://hdl.handle.net/11616/93407
dc.identifier.volume22en_US
dc.identifier.wosWOS:000179785900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectnuclear factor kappa Ben_US
dc.subjectosteoarthritisen_US
dc.titleEffect of caffeic acid phenethyl ester on cartilage in experimental osteoarthritisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu