Can Environmental Enrichment Modulate Epigenetic Processes in the Central Nervous System Under Adverse Environmental Conditions? A Systematic Review

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dc.contributor.authorFernandes, Matheus Santos de Sousa
dc.contributor.authorCosta, Moara Rodrigues
dc.contributor.authorBadicu, Georgian
dc.contributor.authorYagin, Fatma Hilal
dc.contributor.authorSantos, Gabriela Carvalho Jurema
dc.contributor.authorda Costa, Jonathan Manoel
dc.contributor.authorde Souza, Raphael Fabricio
dc.date.accessioned2026-04-04T13:37:29Z
dc.date.available2026-04-04T13:37:29Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractThe aim of this paper is to summarize the available evidence in the literature regarding the effects generated by exposure to an enriched environment (EE) on the modulation of epigenetic processes in the central nervous system under adverse environmental conditions. Searches were conducted in three databases: PubMed/Medline (1053 articles), Scopus (121 articles), and Embase (52 articles), which were subjected to eligibility criteria. Of the 1226 articles found, 173 duplicates were removed. After evaluating titles/abstracts, 904 studies were excluded, resulting in 49 articles, of which 14 were included in this systematic review. EE was performed using different inanimate objects. Adverse environmental conditions included CUMS, sepsis, nicotine exposure, PCP exposure, early stress, WAS, high fructose intake, TBI, and sevoflurane exposure. Regarding microRNA expression, after exposure to EE, an increase in the expression of miR-221 and miR-483 was observed in the prefrontal cortex, and a reduction in the expression of miR-92a-3p and miR-134 in the hippocampus. Regarding histone modifications, in the hippocampus, there was a reduction of HAT, HDAC/HDAC4, H3 (acetyl K14), H4 (acetyl K15), H3K4me3, K3k27me3, and HDAC2/3/5. In the cortex, there was a reduction of HDAC2, and in the prefrontal cortex, there was an increase in acetylated H3. Regarding DNA modifications, there was a reduction of DNMT in the hippocampus. This systematic review concludes that the benefits of EE on the brain and behavior of animals are directly related to different epigenetic mechanisms, reflecting in cell growth and neuroplasticity. EE may be a non-pharmacological and easy-to-apply alternative to prevent symptoms in disorders affecting brain tissue.
dc.identifier.doi10.1007/s10571-024-01506-0
dc.identifier.issn0272-4340
dc.identifier.issn1573-6830
dc.identifier.issue1
dc.identifier.orcid0000-0003-4100-8765
dc.identifier.orcid0000-0002-9848-7958
dc.identifier.pmid39432132
dc.identifier.scopus2-s2.0-85206997650
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10571-024-01506-0
dc.identifier.urihttps://hdl.handle.net/11616/109863
dc.identifier.volume44
dc.identifier.wosWOS:001337734500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofCellular and Molecular Neurobiology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectEnriched environment
dc.subjectEpigenetics
dc.subjectHistones
dc.subjectMicroRNA
dc.subjectNervous system
dc.titleCan Environmental Enrichment Modulate Epigenetic Processes in the Central Nervous System Under Adverse Environmental Conditions? A Systematic Review
dc.typeReview

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