Accelerated atherosclerosis in haemodialysis patients; correlation of endothelial function with oxidative DNA damage

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dc.authoridGeçit, İlhan/0000-0001-7329-6971
dc.authoridHakan, Hamit/0000-0002-9202-4944
dc.authoridAri Bakir, Elif/0000-0001-9208-7972
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridCebi, Aysegul/0000-0003-3804-7966
dc.authorwosidGeçit, İlhan/ABI-8258-2020
dc.authorwosidÇebi, Ayşegül/L-2854-2019
dc.authorwosidHakan, Hamit/U-2671-2018
dc.authorwosidBakan, Ebubekir/K-5431-2019
dc.authorwosidasicioglu, ebru/AAE-8216-2019
dc.authorwosidAri Bakir, Elif/HJH-3482-2023
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.contributor.authorKaya, Yuksel
dc.contributor.authorAri, Elif
dc.contributor.authorDemir, Halit
dc.contributor.authorSoylemez, Nihat
dc.contributor.authorCebi, Aysegul
dc.contributor.authorAlp, Hakan
dc.contributor.authorBakan, Ebubekir
dc.date.accessioned2024-08-04T20:35:53Z
dc.date.available2024-08-04T20:35:53Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Accelerated atherosclerosis is the major cause of mortality in patients on chronic haemodialysis (HD). The aim of this study was to evaluate the relationship between oxidative DNA damage [8-hydroxy-2'-deoxyguanosine/deoxyguanosine ratio (8-OHdG/dG ratio)], oxidative stress biomarkers and endothelial function in HD patients as an indicator of atherosclerosis. Methods. Forty-four chronic HD patients without known atherosclerotic disease and 55 age- and sex-matched healthy individuals were included in the study. Plasma malondialdehyde (MDA) levels and 8-OHdG/dG ratio were determined as oxidative stress markers. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured as antioxidants. Endothelial function was assessed by ultrasonography. Results. 8-OHdG/dG ratio and MDA levels were higher in HD patients than controls while SOD and GPx activities were lower in HD patients compared to controls. Flow-mediated dilatation FMD% in HD patients were lower than the control group (7.28 +/- 0.79 versus 11.18 +/- 0.82, P < 0.001). There was a significant negative correlation between FMD% and 8-OHdG/dG ratio (r = -0.678, P < 0.01) and MDA levels (r = 0.517, P < 0.01), while there was a significant positive correlation between FMD% and SOD (r = 0.538, P < 0.01) and GPx levels (r = 0.720, P < 0.01). Conclusions. Our data have demonstrated that HD patients exhibit increased oxidative DNA damage and decreased antioxidant activity. We propose that endothelial function is negatively correlated with 8-OHdG/dG ratio and positively correlated with antioxidant enzymes. To our knowledge, this is the first study to demonstrate the inverse relationship between endothelial function and plasma oxidative DNA damage in HD patients.en_US
dc.identifier.doi10.1093/ndt/gfr443
dc.identifier.endpage1169en_US
dc.identifier.issn0931-0509
dc.identifier.issn1460-2385
dc.identifier.issue3en_US
dc.identifier.pmid21821836en_US
dc.identifier.scopus2-s2.0-84861164995en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1164en_US
dc.identifier.urihttps://doi.org/10.1093/ndt/gfr443
dc.identifier.urihttps://hdl.handle.net/11616/95657
dc.identifier.volume27en_US
dc.identifier.wosWOS:000301907200049en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectendothelial dysfunctionen_US
dc.subjecthaemodialysisen_US
dc.subjectoxidative DNA damageen_US
dc.titleAccelerated atherosclerosis in haemodialysis patients; correlation of endothelial function with oxidative DNA damageen_US
dc.typeArticleen_US

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