Squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head-and-neck mucosal site treated with radiation therapy alone or in combination with neck dissection

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dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.contributor.authorErkal, HS
dc.contributor.authorMendenhall, WM
dc.contributor.authorAmdur, RJ
dc.contributor.authorVillaret, DB
dc.contributor.authorStringer, SP
dc.date.accessioned2024-08-04T20:12:17Z
dc.date.available2024-08-04T20:12:17Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The present study presents the experience at the University of Florida with treatment of patients with squamous cell carcinomas (SCC) metastatic to cervical lymph nodes from an unknown head-and-neck mucosal (H&NM) site with radiotherapy (RT) alone or in combination with neck dissection (ND), Methods and Materials: The study included 126 patients treated with curative intent from 1964 to 1997. All patients had follow-up for at least 2 years. No patients were lost to follow-up. Results: Twelve patients (10%) developed SCC in H&NM sites at 0.5 to 10.9 years (median, 1.8 years). The rate of developing carcinomas in H&NM sites at 5 years was 13%, Histologic differentiation significantly affected the rate of developing carcinomas in H&NM sites in multivariate analysis, Sixteen patients (13%) had persistent nodal disease and 12 patients (10%) developed recurrent nodal disease at 0.5 to 10.9 years (median, 1.1 years). The nodal control rate at 5 years was 78%. Nodal size, N stage, and planned ND significantly affected the rate of nodal control in multivariate analysis, Nineteen patients (15%) developed distant metastasis at 0.2-5.1 years (median, 0.9 years). The distant metastases rate at 5 years was 14%. Extracapsular extension and RT dose significantly affected the risk of distant metastases in multivariate analysis, The overall absolute survival rate at 5 years was 47%. Extracapsular extension, N stage, RT dose for H&NM sites, and planned ND significantly affected absolute survival in multivariate analysis. The rate of cause-specific survival at 5 fears was 67%, Extracapsular extension, nodal size, N stage, overall treatment time, and planned ND significantly affected cause-specific survival in multivariate analysis, Eight patients (6%) had severe postoperative complications and 6 patients (5%) had severe late complications. Conclusion: The present study supports the effectiveness of RT in lowering the rate of developing carcinomas in the H&NM sites, (C) 2001 Elsevier Science Inc.en_US
dc.identifier.doi10.1016/S0360-3016(00)01554-6
dc.identifier.endpage63en_US
dc.identifier.issn0360-3016
dc.identifier.issn1879-355X
dc.identifier.issue1en_US
dc.identifier.pmid11316546en_US
dc.identifier.scopus2-s2.0-0035341477en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1016/S0360-3016(00)01554-6
dc.identifier.urihttps://hdl.handle.net/11616/93333
dc.identifier.volume50en_US
dc.identifier.wosWOS:000168316200007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthead-and-neck neoplasmsen_US
dc.subjectradiotherapyen_US
dc.subjecttreatment outcomeen_US
dc.titleSquamous cell carcinomas metastatic to cervical lymph nodes from an unknown head-and-neck mucosal site treated with radiation therapy alone or in combination with neck dissectionen_US
dc.typeArticleen_US

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